Seroatlas · Human Serome Atlas

HOMER2

Homer protein homolog 2

Also known as: CPD, Cupidin, DFNA68, HOME2_HUMAN, HOMER-2, HOMER-2A, HOMER-2B, Vesl-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NSB8
Gene
HOMER2
Ensembl
ENSG00000103942
Chromosome
15
Canonical length
354 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>Q9NSB8|HOMER2
     1  MGEQPIFTTR AHVFQIDPNT KKNWMPASKQ AVTVSYFYDV TRNSYRIISV DGAKVIINST
    61  ITPNMTFTKT SQKFGQWADS RANTVFGLGF SSEQQLTKFA EKFQEVKEAA KIAKDKTQEK
   121  IETSSNHSQE SGRETPSSTQ ASSVNGTDDE KASHAGPANT HLKSENDKLK IALTQSAANV
   181  KKWEIELQTL RESNARLTTA LQESAASVEQ WKRQFSICRD ENDRLRNKID ELEEQCSEIN
   241  REKEKNTQLK RRIEELEAEL REKETELKDL RKQSEIIPQL MSECEYVSEK LEAAERDNQN
   301  LEDKVRSLKT DIEESKYRQR HLKVELKSFL EVLDGKIDDL HDFRRGLSKL GTDN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HOMER2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
213 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 213 nTPM
  • skeletal muscle: 102 nTPM
  • salivary gland: 67 nTPM
  • choroid plexus: 65 nTPM
  • prostate: 54 nTPM
  • stomach: 52 nTPM

Single-cell type

  • lacrimal acinar cells: 801 nCPM
  • prostatic glandular cells: 488 nCPM
  • cholangiocytes: 341 nCPM
  • endometrial ciliated cells: 340 nCPM
  • salivary acinar cells: 337 nCPM
  • pancreatic acinar cells: 302 nCPM

Immune cell

  • myeloid DC: 1.1 nTPM
  • eosinophil: 0.4 nTPM
  • neutrophil: 0.4 nTPM
  • plasmacytoid DC: 0.4 nTPM
  • naive B-cell: 0.3 nTPM
  • total PBMC: 0.3 nTPM

Brain region

  • choroid plexus: 162 nTPM
  • hippocampal formation: 48 nTPM
  • cerebral cortex: 40 nTPM
  • cerebellum: 30 nTPM
  • hypothalamus: 30 nTPM
  • white matter: 30 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HOMER2.

Disease | AllUniProt

Conditions HOMER2 is implicated in, by any mechanism.

  • Deafness, autosomal dominant, 68 (DFNA68) MIM:616707

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 225 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Autosomal dominant nonsyndromic hearing loss 68

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0.01
gnomAD missense Z
0.31
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HOMER2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HOMER2 as an antibody target. Whether an autoantibody or antibody against HOMER2 could matter depends on whether native HOMER2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HOMER2 is annotated at the cell surface, where native HOMER2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HOMER2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HOMER2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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