Seroatlas · Human Serome Atlas

SRR

Serine racemase

Also known as: ILV1, ISO1, SRR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9GZT4
Gene
SRR
Ensembl
ENSG00000167720
Chromosome
17
Canonical length
340 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables several functions, including L-serine ammonia-lyase activity; PDZ domain binding activity; and heterocyclic compound binding activity. Involved in carboxylic acid metabolic process and response to lipopolysaccharide. Located in cytoplasm and neuronal cell body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>Q9GZT4|SRR
     1  MCAQYCISFA DVEKAHINIR DSIHLTPVLT SSILNQLTGR NLFFKCELFQ KTGSFKIRGA
    61  LNAVRSLVPD ALERKPKAVV THSSGNHGQA LTYAAKLEGI PAYIVVPQTA PDCKKLAIQA
   121  YGASIVYCEP SDESRENVAK RVTEETEGIM VHPNQEPAVI AGQGTIALEV LNQVPLVDAL
   181  VVPVGGGGML AGIAITVKAL KPSVKVYAAE PSNADDCYQS KLKGKLMPNL YPPETIADGV
   241  KSSIGLNTWP IIRDLVDDIF TVTEDEIKCA TQLVWERMKL LIEPTAGVGV AAVLSQHFQT
   301  VSPEVKNICI VLSGGNVDLT SSITWVKQAE RPASYQSVSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • retina: 15 nTPM
  • skeletal muscle: 15 nTPM
  • bone marrow: 13 nTPM
  • cerebral cortex: 13 nTPM
  • parathyroid gland: 12 nTPM
  • pancreas: 11 nTPM

Single-cell type

  • epicardial cells: 162 nCPM
  • cardiomyocytes: 103 nCPM
  • early primary spermatocytes: 44 nCPM
  • adipocytes: 26 nCPM
  • endometrial secretory cells: 24 nCPM
  • adrenal medulla cells: 21 nCPM

Immune cell

  • myeloid DC: 16 nTPM
  • NK-cell: 16 nTPM
  • non-classical monocyte: 14 nTPM
  • naive CD8 T-cell: 12 nTPM
  • memory CD4 T-cell: 11 nTPM
  • plasmacytoid DC: 11 nTPM

Brain region

  • hypothalamus: 42 nTPM
  • choroid plexus: 40 nTPM
  • thalamus: 40 nTPM
  • midbrain: 40 nTPM
  • medulla oblongata: 40 nTPM
  • cerebellum: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0.01
gnomAD missense Z
0.88
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SRR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRR as an antibody target. Whether an autoantibody or antibody against SRR could matter depends on whether native SRR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SRR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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