Seroatlas · Human Serome Atlas

UBE2H

Ubiquitin-conjugating enzyme E2 H

Also known as: GID3, UBC8, UBCH, UBE2H_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62256
Gene: UBE2H
Ensembl: ENSG00000186591
Chromosome: 7
Canonical length: 183 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>P62256|UBE2H
     1  MSSPSPGKRR MDTDVVKLIE SKHEVTILGG LNEFVVKFYG PQGTPYEGGV WKVRVDLPDK
    61  YPFKSPSIGF MNKIFHPNID EASGTVCLDV INQTWTALYD LTNIFESFLP QLLAYPNPID
   121  PLNGDAAAMY LHRPEEYKQK IKEYIQKYAT EEALKEQEEG TGDSSSESSM SDFSEDEAQD
   181  MEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2H can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 92 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 92 nTPM
pancreas: 80 nTPM
blood vessel: 71 nTPM
skeletal muscle: 70 nTPM
adrenal gland: 64 nTPM
choroid plexus: 57 nTPM

Single-cell type

endometrial glandular cells: 2,955 nCPM
neutrophils: 1,917 nCPM
endometrial luminal cells: 1,593 nCPM
endometrial ciliated cells: 1,215 nCPM
ocular epithelial cells: 1,184 nCPM
salivary acinar cells: 890 nCPM

Immune cell

neutrophil: 4.8 nTPM
naive B-cell: 4.5 nTPM
T-reg: 4.4 nTPM
MAIT T-cell: 3.8 nTPM
naive CD8 T-cell: 3.8 nTPM
naive CD4 T-cell: 3.6 nTPM

Brain region

choroid plexus: 101 nTPM
medulla oblongata: 81 nTPM
thalamus: 75 nTPM
white matter: 75 nTPM
cerebellum: 74 nTPM
cerebral cortex: 73 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UBE2H.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 20 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

UBE2H-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.36
gnomAD pLI: 0.94
gnomAD missense Z: 3.3
DepMap mean gene effect: -0.46
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2H in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2H as an antibody target. Whether an autoantibody or antibody against UBE2H could matter depends on whether native UBE2H is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2H is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2H as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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