Seroatlas · Human Serome Atlas

EIF2B5

Translation initiation factor eIF2B subunit epsilon

Also known as: EI2BE_HUMAN, EIF-2B, EIF2Bepsilon

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13144
Gene
EIF2B5
Ensembl
ENSG00000145191
Chromosome
3
Canonical length
721 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009]

Canonical amino-acid sequenceUniProt

721 residues, UniProt reviewed canonical sequence.

>Q13144|EIF2B5
     1  MAAPVVAPPG VVVSRANKRS GAGPGGSGGG GARGAEEEPP PPLQAVLVAD SFDRRFFPIS
    61  KDQPRVLLPL ANVALIDYTL EFLTATGVQE TFVFCCWKAA QIKEHLLKSK WCRPTSLNVV
   121  RIITSELYRS LGDVLRDVDA KALVRSDFLL VYGDVISNIN ITRALEEHRL RRKLEKNVSV
   181  MTMIFKESSP SHPTRCHEDN VVVAVDSTTN RVLHFQKTQG LRRFAFPLSL FQGSSDGVEV
   241  RYDLLDCHIS ICSPQVAQLF TDNFDYQTRD DFVRGLLVNE EILGNQIHMH VTAKEYGARV
   301  SNLHMYSAVC ADVIRRWVYP LTPEANFTDS TTQSCTHSRH NIYRGPEVSL GHGSILEENV
   361  LLGSGTVIGS NCFITNSVIG PGCHIGDNVV LDQTYLWQGV RVAAGAQIHQ SLLCDNAEVK
   421  ERVTLKPRSV LTSQVVVGPN ITLPEGSVIS LHPPDAEEDE DDGEFSDDSG ADQEKDKVKM
   481  KGYNPAEVGA AGKGYLWKAA GMNMEEEEEL QQNLWGLKIN MEEESESESE QSMDSEEPDS
   541  RGGSPQMDDI KVFQNEVLGT LQRGKEENIS CDNLVLEINS LKYAYNISLK EVMQVLSHVV
   601  LEFPLQQMDS PLDSSRYCAL LLPLLKAWSP VFRNYIKRAA DHLEALAAIE DFFLEHEALG
   661  ISMAKVLMAF YQLEILAEET ILSWFSQRDT TDKGQQLRKN QQLQRFIQWL KEAEEESSED
   721  D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF2B5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
50 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 50 nTPM
  • tongue: 31 nTPM
  • choroid plexus: 21 nTPM
  • esophagus: 21 nTPM
  • parathyroid gland: 21 nTPM
  • skin: 19 nTPM

Single-cell type

  • epididymal principal cells: 61 nCPM
  • esophageal basal cells: 60 nCPM
  • esophageal suprabasal cells: 60 nCPM
  • esophageal apical cells: 53 nCPM
  • cytotrophoblasts: 46 nCPM
  • migrating cytotrophoblasts: 43 nCPM

Immune cell

  • naive CD4 T-cell: 18 nTPM
  • naive B-cell: 17 nTPM
  • memory B-cell: 16 nTPM
  • eosinophil: 15 nTPM
  • NK-cell: 14 nTPM
  • memory CD8 T-cell: 13 nTPM

Brain region

  • choroid plexus: 13 nTPM
  • hypothalamus: 9.5 nTPM
  • cerebral cortex: 8.6 nTPM
  • cerebellum: 8.5 nTPM
  • medulla oblongata: 8.3 nTPM
  • spinal cord: 8.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EIF2B5.

Disease | AllUniProt

Conditions EIF2B5 is implicated in, by any mechanism.

  • Leukoencephalopathy with vanishing white matter 5 (VWM5) MIM:620315

Disease | GeneticClinVar

117 pathogenic / likely-pathogenic of 861 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.06
gnomAD missense Z
0.78
DepMap mean gene effect
-1.19
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 16% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF2B5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF2B5 as an antibody target. Whether an autoantibody or antibody against EIF2B5 could matter depends on whether native EIF2B5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF2B5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF2B5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF2B5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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