Seroatlas · Human Serome Atlas

RILPL2

RILP-like protein 2

Also known as: FLJ30380, FLJ32372, MGC7036, RIPL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969X0
Gene: RILPL2
Ensembl: ENSG00000150977
Chromosome: 12
Canonical length: 211 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Primary cilium,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein that contains a rab-interacting lysosomal protein-like domain. This protein may be involved in regulating lysosome morphology. This protein may also be a target for the Hepatitis C virus and assist in viral replication. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

211 residues, UniProt reviewed canonical sequence.

>Q969X0|RILPL2
     1  MEEPPVREEE EEEGEEDEER DEVGPEGALG KSPFQLTAED VYDISYLLGR ELMALGSDPR
    61  VTQLQFKVVR VLEMLEALVN EGSLALEELK MERDHLRKEV EGLRRQSPPA SGEVNLGPNK
   121  MVVDLTDPNR PRFTLQELRD VLQERNKLKS QLLVVQEELQ CYKSGLIPPR EGPGGRREKD
   181  AVVTSAKNAG RNKEEKTIIK KLFFFRSGKQ T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RILPL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 110 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 110 nTPM
blood vessel: 47 nTPM
spleen: 35 nTPM
choroid plexus: 34 nTPM
lung: 33 nTPM
thyroid gland: 28 nTPM

Single-cell type

neutrophils: 3,538 nCPM
monocytes: 792 nCPM
monocyte progenitors: 473 nCPM
neutrophil progenitors: 456 nCPM
megakaryocytes: 433 nCPM
cdc: 391 nCPM

Immune cell

neutrophil: 177 nTPM
eosinophil: 160 nTPM
classical monocyte: 133 nTPM
non-classical monocyte: 122 nTPM
intermediate monocyte: 106 nTPM
basophil: 99 nTPM

Brain region

choroid plexus: 18 nTPM
hypothalamus: 11 nTPM
cerebral cortex: 10 nTPM
medulla oblongata: 9.3 nTPM
midbrain: 9.3 nTPM
thalamus: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RILPL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RILPL2 as an antibody target. Whether an autoantibody or antibody against RILPL2 could matter depends on whether native RILPL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RILPL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RILPL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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