Seroatlas · Human Serome Atlas

MICAL2

[F-actin]-monooxygenase MICAL2

Also known as: FLJ14966, KIAA0750, MICA2_HUMAN, MICALCL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O94851
Gene
MICAL2
Ensembl
ENSG00000133816
Chromosome
11
Canonical length
1957 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

1957 residues, UniProt reviewed canonical sequence.

>O94851|MICAL2
     1  MGENEDEKQA QAGQVFENFV QASTCKGTLQ AFNILTRHLD LDPLDHRNFY SKLKSKVTTW
    61  KAKALWYKLD KRGSHKEYKR GKSCTNTKCL IVGGGPCGLR TAIELAYLGA KVVVVEKRDS
   121  FSRNNVLHLW PFTIHDLRGL GAKKFYGKFC AGSIDHISIR QLQLILFKVA LMLGVEIHVN
   181  VEFVKVLEPP EDQENQKIGW RAEFLPTDHS LSEFEFDVII GADGRRNTLE GFRRKEFRGK
   241  LAIAITANFI NRNSTAEAKV EEISGVAFIF NQKFFQDLKE ETGIDLENIV YYKDCTHYFV
   301  MTAKKQSLLD KGVIINDYID TEMLLCAENV NQDNLLSYAR EAADFATNYQ LPSLDFAMNH
   361  YGQPDVAMFD FTCMYASENA ALVRERQAHQ LLVALVGDSL LEPFWPMGTG CARGFLAAFD
   421  TAWMVKSWNQ GTPPLELLAE RESLYRLLPQ TTPENINKNF EQYTLDPGTR YPNLNSHCVR
   481  PHQVKHLYIT KELEHYPLER LGSVRRSVNL SRKESDIRPS KLLTWCQQQT EGYQHVNVTD
   541  LTTSWRSGLA LCAIIHRFRP ELINFDSLNE DDAVENNQLA FDVAEREFGI PPVTTGKEMA
   601  SAQEPDKLSM VMYLSKFYEL FRGTPLRPVD SWRKNYGENA DLSLAKSSIS NNYLNLTFPR
   661  KRTPRVDGQT GENDMNKRRR KGFTNLDEPS NFSSRSLGSN QECGSSKEGG NQNKVKSMAN
   721  QLLAKFEEST RNPSLMKQER RVSGIGKPVL CSSSGPPVHS CCPKPEEATP SPSPPLKRQF
   781  PSVVVTGHVL RELKQVSAGS ECLSRPWRAR AKSDLQLGGT ENFATLPSTR PRAQALSGVL
   841  WRLQQVEEKI LQKRAQNLAN REFHTKNIKE KAAHLASMFG HGDFPQNKLL SKGLSHTHPP
   901  SPPSRLPSPD PAASSSPSTV DSASPARKEK KSPSGFHFHP SHLRTVHPQL TVGKVSSGIG
   961  AAAEVLVNLY MNDHRPKAQA TSPDLESMRK SFPLNLGGSD TCYFCKKRVY VMERLSAEGH
  1021  FFHRECFRCS ICATTLRLAA YTFDCDEGKF YCKPHFIHCK TNSKQRKRRA ELKQQREEEA
  1081  TWQEQEAPRR DTPTESSCAV AAIGTLEGSP PDEPTSPKRP KSISEPQHSD AEGDAASPLP
  1141  SEWTSVRISP GEEAAGQDVL AVRVLVTSED SSSDTESDYG GSEGSHTEPC EEKPWRPGSP
  1201  HLPHTSLGEA LSRAVSPQCP EEPRAVHAAL QRANSFQSPT PSKYQNWRRE FWWSLTPVNK
  1261  RTMSPPKDPS PSLPLPSSSS HSSSPPSSSS TSVSGNAPDG SSPPQMTASE PLSQVSRGHP
  1321  SPPTPNFRRR AVAQGAPREI PLYLPHHPKP EWAEYCLVSP GEDGLSDPAE MTSDECQPAE
  1381  APLGDIGSNH RDPHPIWGKD RSWTGQELSP LAGEDREKGS TGARKEEEGG PVLVKEKLGL
  1441  KKLVLTQEQK TMLLDWNDSI PESVHLKAGE RISQKSAENG RGGRVLKPVR PLLLPRAAGE
  1501  PLPTQRGAQE KMGTPAEQAQ GERNVPPPKS PLRLIANAIR RSLEPLLSNS EGGKKAWAKQ
  1561  ESKTLPAQAC TRSFSLRKTN SNKDGDQHSP GRNQSSAFSP PDPALRTHSL PNRPSKVFPA
  1621  LRSPPCSKIE DVPTLLEKVS LQENFPDASK PPKKRISLFS SLRLKDKSFE SFLQESRQRK
  1681  DIRDLFGSPK RKVLPEDSAQ ALEKLLQPFK STSLRQAAPP PPPPPPPPPP PPTAGGADSK
  1741  NFPLRAQVTE ASSSASSTSS SSADEEFDPQ LSLQLKEKKT LRRRKKLEKA MKQLVKQEEL
  1801  KRLYKAQAIQ RQLEEVEERQ RASEIQGVRL EKALRGEADS GTQDEAQLLQ EWFKLVLEKN
  1861  KLMRYESELL IMAQELELED HQSRLEQKLR EKMLKEESQK DEKDLNEEQE VFTELMQVIE
  1921  QRDKLVDSLE EQRIREKAED QHFESFVFSR GCQLSRT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MICAL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
138 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 138 nTPM
  • cerebral cortex: 47 nTPM
  • heart muscle: 47 nTPM
  • smooth muscle: 44 nTPM
  • testis: 43 nTPM
  • blood vessel: 29 nTPM

Single-cell type

  • choroid plexus epithelial cells: 659 nCPM
  • sertoli cells: 487 nCPM
  • alveolar cells type 2: 475 nCPM
  • alveolar cells type 1: 425 nCPM
  • late spermatids: 409 nCPM
  • colonocytes: 371 nCPM

Immune cell

  • neutrophil: 12 nTPM
  • classical monocyte: 7.4 nTPM
  • myeloid DC: 5.9 nTPM
  • NK-cell: 4 nTPM
  • MAIT T-cell: 2.6 nTPM
  • total PBMC: 2.6 nTPM

Brain region

  • choroid plexus: 231 nTPM
  • cerebellum: 229 nTPM
  • hippocampal formation: 183 nTPM
  • cerebral cortex: 178 nTPM
  • white matter: 137 nTPM
  • amygdala: 112 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0
gnomAD missense Z
0.79
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MICAL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MICAL2 as an antibody target. Whether an autoantibody or antibody against MICAL2 could matter depends on whether native MICAL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MICAL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MICAL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MICAL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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