Seroatlas · Human Serome Atlas

MICAL1

[F-actin]-monooxygenase MICAL1

Also known as: DKFZp434B1517, FLJ11937, FLJ21739, MICA1_HUMAN, MICAL, NICAL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TDZ2
Gene
MICAL1
Ensembl
ENSG00000135596
Chromosome
6
Canonical length
1067 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Primary cilium,Basal body,Cytosol

OverviewNCBI Gene

This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

1067 residues, UniProt reviewed canonical sequence.

>Q8TDZ2|MICAL1
     1  MASPTSTNPA HAHFESFLQA QLCQDVLSSF QELCGALGLE PGGGLPQYHK IKDQLNYWSA
    61  KSLWTKLDKR AGQPVYQQGR ACTSTKCLVV GAGPCGLRVA VELALLGARV VLVEKRTKFS
   121  RHNVLHLWPF TIHDLRALGA KKFYGRFCTG TLDHISIRQL QLLLLKVALL LGVEIHWGVT
   181  FTGLQPPPRK GSGWRAQLQP NPPAQLANYE FDVLISAAGG KFVPEGFKVR EMRGKLAIGI
   241  TANFVNGRTV EETQVPEISG VARIYNQSFF QSLLKATGID LENIVYYKDD THYFVMTAKK
   301  QCLLRLGVLR QDWPDTNRLL GSANVVPEAL QRFTRAAADF ATHGKLGKLE FAQDAHGQPD
   361  VSAFDFTSMM RAESSARVQE KHGARLLLGL VGDCLVEPFW PLGTGVARGF LAAFDAAWMV
   421  KRWAEGAESL EVLAERESLY QLLSQTSPEN MHRNVAQYGL DPATRYPNLN LRAVTPNQVR
   481  DLYDVLAKEP VQRNNDKTDT GMPATGSAGT QEELLRWCQE QTAGYPGVHV SDLSSSWADG
   541  LALCALVYRL QPGLLEPSEL QGLGALEATA WALKVAENEL GITPVVSAQA VVAGSDPLGL
   601  IAYLSHFHSA FKSMAHSPGP VSQASPGTSS AVLFLSKLQR TLQRSRAKEN AEDAGGKKLR
   661  LEMEAETPST EVPPDPEPGV PLTPPSQHQE AGAGDLCALC GEHLYVLERL CVNGHFFHRS
   721  CFRCHTCEAT LWPGGYEQHP GDGHFYCLQH LPQTDHKAEG SDRGPESPEL PTPSENSMPP
   781  GLSTPTASQE GAGPVPDPSQ PTRRQIRLSS PERQRLSSLN LTPDPEMEPP PKPPRSCSAL
   841  ARHALESSFV GWGLPVQSPQ ALVAMEKEEK ESPFSSEEEE EDVPLDSDVE QALQTFAKTS
   901  GTMNNYPTWR RTLLRRAKEE EMKRFCKAQT IQRRLNEIEA ALRELEAEGV KLELALRRQS
   961  SSPEQQKKLW VGQLLQLVDK KNSLVAEEAE LMITVQELNL EEKQWQLDQE LRGYMNREEN
  1021  LKTAADRQAE DQVLRKLVDL VNQRDALIRF QEERRLSELA LGTGAQG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MICAL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 74 nTPM
  • bone marrow: 62 nTPM
  • spleen: 59 nTPM
  • blood vessel: 48 nTPM
  • small intestine: 44 nTPM
  • fallopian tube: 39 nTPM

Single-cell type

  • neutrophils: 86 nCPM
  • neutrophil progenitors: 85 nCPM
  • smooth muscle cells: 67 nCPM
  • decidual stromal cells: 62 nCPM
  • pdcs: 60 nCPM
  • vascular smooth muscle cells: 58 nCPM

Immune cell

  • basophil: 15 nTPM
  • plasmacytoid DC: 14 nTPM
  • non-classical monocyte: 14 nTPM
  • eosinophil: 14 nTPM
  • intermediate monocyte: 13 nTPM
  • myeloid DC: 13 nTPM

Brain region

  • white matter: 26 nTPM
  • medulla oblongata: 23 nTPM
  • pons: 22 nTPM
  • thalamus: 22 nTPM
  • hypothalamus: 21 nTPM
  • cerebral cortex: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MICAL1.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 1,306 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
-0.24
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MICAL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MICAL1 as an antibody target. Whether an autoantibody or antibody against MICAL1 could matter depends on whether native MICAL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MICAL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MICAL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MICAL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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