Seroatlas · Human Serome Atlas

PPP6R1

Serine/threonine-protein phosphatase 6 regulatory subunit 1

Also known as: KIAA1115, PP6R1_HUMAN, SAP190, SAPS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UPN7
Gene
PPP6R1
Ensembl
ENSG00000105063
Chromosome
19
Canonical length
881 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

881 residues, UniProt reviewed canonical sequence.

>Q9UPN7|PPP6R1
     1  MFWKFDLHTS SHLDTLLERE DLSLPELLDE EDVLQECKVV NRKLLDFLLQ PPHLQAMVAW
    61  VTQEPPDSGE ERLRYKYPSV ACEILTSDVP QINDALGADE SLLNRLYGFL QSTGSLNPLL
   121  ASFFSKVMGI LINRKTDQLV SFLRKKDDFV DLLLQHIGTS AIMDLLLRLL TCVERPQLRQ
   181  DVVNWLNEEK IVQRLIEQIH PSKDENQHSN ASQSLCDIIR LSREQMIQVQ DSPEPDQLLA
   241  TLEKQETIEQ LLSNMFEGEQ SQSVIVSGIQ VLLTLLEPRR PRSESVTVNS FFSSVDGQLE
   301  LLAQGALEST VSSVGALHAL RPRLSCFHQL LLEPPKLEPL QMTWGMLAPP LGNTRLHVVK
   361  LLASALSAND AALTHELLAL DVPNTMLDLF FHYVFNNFLH AQVEGCVSTM LSLGPPPDSS
   421  PETPIQNPVV KHLLQQCRLV ERILTSWEEN DRVQCAGGPR KGYMGHLTRV AGALVQNTEK
   481  GPNAEQLRQL LKELPSEQQE QWEAFVSGPL AETNKKNMVD LVNTHHLHSS SDDEDDRLKE
   541  FNFPEEAVLQ QAFMDFQMQR MTSAFIDHFG FNDEEFGEQE ESVNAPFDKT ANITFSLNAD
   601  DENPNANLLE ICYKDRIQQF DDDEEEEDEE EAQGSGESDG EDGAWQGSQL ARGARLGQPP
   661  GVRSGGSTDS EDEEEEDEEE EEDEEGIGCA ARGGATPLSY PSPGPQPPGP SWTATFDPVP
   721  TDAPTSPRVS GEEELHTGPP APQGPLSVPQ GLPTQSLASP PARDALQLRS QDPTPPSAPQ
   781  EATEGSKVTE PSAPCQALVS IGDLQATFHG IRSAPSSSDS ATRDPSTSVP ASGAHQPPQT
   841  TEGEKSPEPL GLPQSQSAQA LTPPPIPNGS APEGPASPGS Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP6R1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
91 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 91 nTPM
  • testis: 85 nTPM
  • lymph node: 77 nTPM
  • spleen: 58 nTPM
  • thymus: 58 nTPM
  • hippocampal formation: 51 nTPM

Single-cell type

  • early spermatids: 237 nCPM
  • late primary spermatocytes: 88 nCPM
  • late spermatids: 61 nCPM
  • megakaryocytes: 43 nCPM
  • foveolar cells: 42 nCPM
  • megakaryocyte-erythroid progenitors: 42 nCPM

Immune cell

  • plasmacytoid DC: 29 nTPM
  • gdT-cell: 12 nTPM
  • memory CD8 T-cell: 9.3 nTPM
  • NK-cell: 7.8 nTPM
  • naive CD8 T-cell: 7.5 nTPM
  • total PBMC: 6.8 nTPM

Brain region

  • hippocampal formation: 115 nTPM
  • cerebral cortex: 101 nTPM
  • basal ganglia: 101 nTPM
  • amygdala: 94 nTPM
  • thalamus: 70 nTPM
  • choroid plexus: 69 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.98
gnomAD missense Z
0.04
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP6R1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP6R1 as an antibody target. Whether an autoantibody or antibody against PPP6R1 could matter depends on whether native PPP6R1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP6R1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP6R1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPP6R1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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