Seroatlas · Human Serome Atlas

PPP6R3

Serine/threonine-protein phosphatase 6 regulatory subunit 3

Also known as: C11orf23, DKFZp781E17107, DKFZp781E2374, DKFZp781O2362, FLJ11058, FLJ43065, KIAA1558, MGC125711, MGC125712, PP6R3, PP6R3_HUMAN, SAP190, SAPL, SAPLa, SAPS3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5H9R7
Gene: PPP6R3
Ensembl: ENSG00000110075
Chromosome: 11
Canonical length: 873 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

873 residues, UniProt reviewed canonical sequence.

>Q5H9R7|PPP6R3
     1  MFWKFDLHSS SHIDTLLERE DVTLKELMDE EDVLQECKAQ NRKLIEFLLK AECLEDLVSF
    61  IIEEPPQDMD EKIRYKYPNI SCELLTSDVS QMNDRLGEDE SLLMKLYSFL LNDSPLNPLL
   121  ASFFSKVLSI LISRKPEQIV DFLKKKHDFV DLIIKHIGTS AIMDLLLRLL TCIEPPQPRQ
   181  DVLNWLNEEK IIQRLVEIVH PSQEEDRHSN ASQSLCEIVR LSRDQMLQIQ NSTEPDPLLA
   241  TLEKQEIIEQ LLSNIFHKEK NESAIVSAIQ ILLTLLETRR PTFEGHIEIC PPGMSHSACS
   301  VNKSVLEAIR GRLGSFHELL LEPPKKSVMK TTWGVLDPPV GNTRLNVIRL ISSLLQTNTS
   361  SINGDLMELN SIGVILNMFF KYTWNNFLHT QVEICIALIL ASPFENTENA TITDQDSTGD
   421  NLLLKHLFQK CQLIERILEA WEMNEKKQAE GGRRHGYMGH LTRIANCIVH STDKGPNSAL
   481  VQQLIKDLPD EVRERWETFC TSSLGETNKR NTVDLVTTCH IHSSSDDEID FKETGFSQDS
   541  SLQQAFSDYQ MQQMTSNFID QFGFNDEKFA DQDDIGNVSF DRVSDINFTL NTNESGNIAL
   601  FEACCKERIQ QFDDGGSDEE DIWEEKHIAF TPESQRRSSS GSTDSEESTD SEEEDGAKQD
   661  LFEPSSANTE DKMEVDLSEP PNWSANFDVP METTHGAPLD SVGSDVWSTE EPMPTKETGW
   721  ASFSEFTSSL STKDSLRSNS PVEMETSTEP MDPLTPSAAA LAVQPEAAGS VAMEASSDGE
   781  EDAESTDKVT ETVMNGGMKE TLSLTVDAKT ETAVFKSEEG KLSTSQDAAC KDAEECPETA
   841  EAKCAAPRPP SSSPEQRTGQ PSAPGDTSVN GPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP6R3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 50 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 50 nTPM
skeletal muscle: 46 nTPM
tongue: 46 nTPM
thymus: 41 nTPM
thyroid gland: 41 nTPM
parathyroid gland: 40 nTPM

Single-cell type

myonuclei: 657 nCPM
neutrophils: 650 nCPM
adrenal cortex cells: 563 nCPM
neutrophil progenitors: 494 nCPM
sertoli cells: 487 nCPM
cardiomyocytes: 420 nCPM

Immune cell

non-classical monocyte: 16 nTPM
basophil: 15 nTPM
neutrophil: 14 nTPM
naive CD4 T-cell: 14 nTPM
eosinophil: 13 nTPM
intermediate monocyte: 13 nTPM

Brain region

cerebellum: 88 nTPM
white matter: 85 nTPM
choroid plexus: 78 nTPM
basal ganglia: 70 nTPM
pons: 68 nTPM
medulla oblongata: 67 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.99
gnomAD missense Z: 1.54
DepMap mean gene effect: -0.34
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of signal transduction

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP6R3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP6R3 as an antibody target. Whether an autoantibody or antibody against PPP6R3 could matter depends on whether native PPP6R3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP6R3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP6R3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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