Seroatlas · Human Serome Atlas

PPP6R2

Serine/threonine-protein phosphatase 6 regulatory subunit 2

Also known as: dJ579N16.1, KIAA0685, PP6R2_HUMAN, SAP190, SAPS2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75170
Gene: PPP6R2
Ensembl: ENSG00000100239
Chromosome: 22
Canonical length: 966 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol,Cytoplasmic bodies

OverviewNCBI Gene

The protein encoded by this gene is a regulatory protein for the protein phosphatase-6 catalytic subunit. Together, these proteins act as a significant T-loop phosphatase for Aurora A, an essential mitotic kinase. Loss of function of either the regulatory or catalytic subunit of protein phosphatase-6 interferes with spindle formation and chromosome alignment. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

966 residues, UniProt reviewed canonical sequence.

>O75170|PPP6R2
     1  MFWKFDLNTT SHVDKLLDKE HVTLQELMDE DDILQECKAQ NQKLLDFLCR QQCMEELVSL
    61  ITQDPPLDME EKVRFKYPNT ACELLTCDVP QISDRLGGDE SLLSLLYDFL DHEPPLNPLL
   121  ASFFSKTIGN LIARKTEQVI TFLKKKDKFI SLVLKHIGTS ALMDLLLRLV SCVEPAGLRQ
   181  DVLHWLNEEK VIQRLVELIH PSQDEDRQSN ASQTLCDIVR LGRDQGSQLQ EALEPDPLLT
   241  ALESQDCVEQ LLKNMFDGDR TESCLVSGTQ VLLTLLETRR VGTEGLVDSF SQGLERSYAV
   301  SSSVLHGIEP RLKDFHQLLL NPPKKKAILT TIGVLEEPLG NARLHGARLM AALLHTNTPS
   361  INQELCRLNT MDLLLDLFFK YTWNNFLHFQ VELCIAAILS HAAREERTEA SGSESRVEPP
   421  HENGNRSLET PQPAASLPDN TMVTHLFQKC CLVQRILEAW EANDHTQAAG GMRRGNMGHL
   481  TRIANAVVQN LERGPVQTHI SEVIRGLPAD CRGRWESFVE ETLTETNRRN TVDLVSTHHL
   541  HSSSEDEDIE GAFPNELSLQ QAFSDYQIQQ MTANFVDQFG FNDEEFADQD DNINAPFDRI
   601  AEINFNIDAD EDSPSAALFE ACCSDRIQPF DDDEDEDIWE DSDTRCAARV MARPRFGAPH
   661  ASESCSKNGP ERGGQDGKAS LEAHRDAPGA GAPPAPGKKE APPVEGDSEG AMWTAVFDEP
   721  ANSTPTAPGV VRDVGSSVWA AGTSAPEEKG WAKFTDFQPF CCSESGPRCS SPVDTECSHA
   781  EGSRSQGPEK ASQASYFAVS PASPCAWNVC VTRKAPLLAS DSSSSGGSHS EDGDQKAASA
   841  MDAVSRGPGR EAPPLPTVAR TEEAVGRVGC ADSRLLSPAC PAPKEVTAAP AVAVPPEATV
   901  AITTALSKAG PAIPTPAVSS ALAVAVPLGP IMAVTAAPAM VATLGTVTKD GKTDAPPEGA
   961  ALNGPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP6R2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 71 nTPM

Expression across tissuesHPA

Tissue

liver: 71 nTPM
skeletal muscle: 65 nTPM
testis: 61 nTPM
cerebellum: 51 nTPM
pituitary gland: 41 nTPM
heart muscle: 35 nTPM

Single-cell type

myonuclei: 380 nCPM
retinal ganglion cells: 317 nCPM
distal convoluted tubule cells: 288 nCPM
proximal tubule cells: 287 nCPM
microglia: 279 nCPM
loop of henle epithelial cells: 247 nCPM

Immune cell

neutrophil: 14 nTPM
T-reg: 13 nTPM
plasmacytoid DC: 11 nTPM
MAIT T-cell: 11 nTPM
memory CD8 T-cell: 9.7 nTPM
intermediate monocyte: 9.4 nTPM

Brain region

cerebral cortex: 68 nTPM
medulla oblongata: 64 nTPM
thalamus: 62 nTPM
white matter: 60 nTPM
hippocampal formation: 60 nTPM
amygdala: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.16
gnomAD missense Z: 0.93
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of signal transduction

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP6R2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP6R2 as an antibody target. Whether an autoantibody or antibody against PPP6R2 could matter depends on whether native PPP6R2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP6R2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP6R2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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