PNRC1
Proline-rich nuclear receptor coactivator 1
Also known as: B4-2, PNRC1_HUMAN, PROL2, PRR2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q12796
- Gene
- PNRC1
- Ensembl
- ENSG00000146278
- Chromosome
- 6
- Canonical length
- 327 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to be active in P-body and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
327 residues, UniProt reviewed canonical sequence.
>Q12796|PNRC1
1 MTVVSVPQRE PLVLGGRLAP LGFSSRGYFG ALPMVTTAPP PLPRIPDPRA LPPTLFLPHF
61 LGGDGPCLTP QPRAPAALPN RSLAVAGGTP RAAPKKRRKK KVRASPAGQL PSRFHQYQQH
121 RPSLEGGRSP ATGPSGAQEV PGPAAALAPS PAAAAGTEGA SPDLAPLRPA APGQTPLRKE
181 VLKSKMGKSE KIALPHGQLV HGIHLYEQPK INRQKSKYNL PLTKITSAKR NENNFWQDSV
241 SSDRIQKQEK KPFKNTENIK NSHLKKSAFL TEVSQKENYA GAKFSDPPSP SVLPKPPSHW
301 MGSTVENSNQ NRELMAVHLK TLLKVQTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PNRC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.73
- Highest tissue expression
- 388 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 388 nTPM
- bone marrow: 348 nTPM
- liver: 297 nTPM
- blood vessel: 214 nTPM
- adipose tissue: 202 nTPM
- ovary: 195 nTPM
Single-cell type
- neutrophils: 2,908 nCPM
- epididymal basal cells: 1,231 nCPM
- monocytes: 1,177 nCPM
- epididymal efferent duct absorptive cells: 1,110 nCPM
- endometrial luminal cells: 1,031 nCPM
- smooth muscle cells: 964 nCPM
Immune cell
- eosinophil: 104 nTPM
- neutrophil: 101 nTPM
- basophil: 33 nTPM
- naive CD8 T-cell: 26 nTPM
- naive CD4 T-cell: 25 nTPM
- naive B-cell: 23 nTPM
Brain region
- medulla oblongata: 214 nTPM
- cerebellum: 200 nTPM
- white matter: 188 nTPM
- hypothalamus: 185 nTPM
- spinal cord: 175 nTPM
- pons: 174 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.39
- gnomAD pLI
- 0.91
- gnomAD missense Z
- 0.73
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- nonsense-mediated decay
- nuclear-transcribed mRNA catabolic process
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PNRC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PNRC1 as an antibody target. Whether an autoantibody or antibody against PNRC1 could matter depends on whether native PNRC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PNRC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PNRC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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