Seroatlas · Human Serome Atlas

POU2F2

POU domain, class 2, transcription factor 2

Also known as: OCT2, OTF2, PO2F2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P09086
Gene: POU2F2
Ensembl: ENSG00000028277
Chromosome: 19
Canonical length: 479 aa
Protein class: Cancer-related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

479 residues, UniProt reviewed canonical sequence.

>P09086|POU2F2
     1  MVHSSMGAPE IRMSKPLEAE KQGLDSPSEH TDTERNGPDT NHQNPQNKTS PFSVSPTGPS
    61  TKIKAEDPSG DSAPAAPLPP QPAQPHLPQA QLMLTGSQLA GDIQQLLQLQ QLVLVPGHHL
   121  QPPAQFLLPQ AQQSQPGLLP TPNLFQLPQQ TQGALLTSQP RAGLPTQAVT RPTLPDPHLS
   181  HPQPPKCLEP PSHPEEPSDL EELEQFARTF KQRRIKLGFT QGDVGLAMGK LYGNDFSQTT
   241  ISRFEALNLS FKNMCKLKPL LEKWLNDAET MSVDSSLPSP NQLSSPSLGF DGLPGRRRKK
   301  RTSIETNVRF ALEKSFLANQ KPTSEEILLI AEQLHMEKEV IRVWFCNRRQ KEKRINPCSA
   361  APMLPSPGKP ASYSPHMVTP QGGAGTLPLS QASSSLSTTV TTLSSAVGTL HPSRTAGGGG
   421  GGGGAAPPLN SIPSVTPPPP ATTNSTNPSP QGSHSAIGLS GLNPSTGPGL WWNPAPYQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POU2F2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

lymph node: 47 nTPM
tonsil: 46 nTPM
appendix: 25 nTPM
spleen: 24 nTPM
small intestine: 9.7 nTPM
testis: 7.7 nTPM

Single-cell type

b-cells: 341 nCPM
monocytes: 259 nCPM
cdc: 168 nCPM
neutrophils: 166 nCPM
early primary spermatocytes: 156 nCPM
plasma cells: 145 nCPM

Immune cell

non-classical monocyte: 95 nTPM
intermediate monocyte: 51 nTPM
naive B-cell: 33 nTPM
memory B-cell: 29 nTPM
classical monocyte: 28 nTPM
myeloid DC: 21 nTPM

Brain region

hypothalamus: 29 nTPM
cerebellum: 29 nTPM
pons: 18 nTPM
cerebral cortex: 18 nTPM
midbrain: 16 nTPM
medulla oblongata: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.2
gnomAD pLI: 1
gnomAD missense Z: 2.6
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POU2F2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POU2F2 as an antibody target. Whether an autoantibody or antibody against POU2F2 could matter depends on whether native POU2F2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POU2F2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POU2F2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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