PRMT2
Protein arginine N-methyltransferase 2
Also known as: ANM2_HUMAN, HRMT1L1, MGC111373
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P55345
- Gene
- PRMT2
- Ensembl
- ENSG00000160310
- Chromosome
- 21
- Canonical length
- 433 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Enables several functions, including nuclear receptor binding activity; peroxisome proliferator activated receptor binding activity; and protein homodimerization activity. Involved in positive regulation of apoptotic process; regulation of DNA-templated transcription; and regulation of androgen receptor signaling pathway. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
433 residues, UniProt reviewed canonical sequence.
>P55345|PRMT2
1 MATSGDCPRS ESQGEEPAEC SEAGLLQEGV QPEEFVAIAD YAATDETQLS FLRGEKILIL
61 RQTTADWWWG ERAGCCGYIP ANHVGKHVDE YDPEDTWQDE EYFGSYGTLK LHLEMLADQP
121 RTTKYHSVIL QNKESLTDKV ILDVGCGTGI ISLFCAHYAR PRAVYAVEAS EMAQHTGQLV
181 LQNGFADIIT VYQQKVEDVV LPEKVDVLVS EWMGTCLLFE FMIESILYAR DAWLKEDGVI
241 WPTMAALHLV PCSADKDYRS KVLFWDNAYE FNLSALKSLA VKEFFSKPKY NHILKPEDCL
301 SEPCTILQLD MRTVQISDLE TLRGELRFDI RKAGTLHGFT AWFSVHFQSL QEGQPPQVLS
361 TGPFHPTTHW KQTLFMMDDP VPVHTGDVVT GSVVLQRNPV WRRHMSVALS WAVTSRQDPT
421 SQKVGEKVFP IWRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PRMT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 92 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 92 nTPM
- hypothalamus: 85 nTPM
- ovary: 78 nTPM
- choroid plexus: 74 nTPM
- midbrain: 73 nTPM
- cerebral cortex: 68 nTPM
Single-cell type
- esophageal apical cells: 360 nCPM
- megakaryocytes: 321 nCPM
- platelets: 314 nCPM
- nk-cells: 267 nCPM
- esophageal suprabasal cells: 250 nCPM
- microglia: 229 nCPM
Immune cell
- eosinophil: 313 nTPM
- gdT-cell: 260 nTPM
- NK-cell: 259 nTPM
- basophil: 255 nTPM
- naive CD8 T-cell: 246 nTPM
- memory CD8 T-cell: 225 nTPM
Brain region
- midbrain: 178 nTPM
- hypothalamus: 135 nTPM
- pons: 134 nTPM
- white matter: 132 nTPM
- medulla oblongata: 129 nTPM
- thalamus: 124 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.65
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.79
- DepMap mean gene effect
- -0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- chromatin remodeling
- developmental cell growth
- negative regulation of canonical NF-kappaB signal transduction
- negative regulation of DNA-templated transcription
- negative regulation of G1/S transition of mitotic cell cycle
- negative regulation of inflammatory response
- negative regulation of NF-kappaB transcription factor activity
- positive regulation of apoptotic process
- positive regulation of DNA-templated transcription
- protein methylation
- regulation of androgen receptor signaling pathway
- regulation of DNA-templated transcription
- signal transduction
Molecular functions
- histone H3 methyltransferase activity
- histone methyltransferase activity
- nuclear androgen receptor binding
- nuclear estrogen receptor binding
- nuclear progesterone receptor binding
- nuclear retinoic acid receptor binding
- nuclear thyroid hormone receptor binding
- peroxisome proliferator activated receptor binding
- protein homodimerization activity
- protein-arginine N-methyltransferase activity
- protein-arginine omega-N asymmetric methyltransferase activity
- protein-containing complex binding
- transcription coactivator activity
- histone H3R8 methyltransferase activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
- SH3 domain
- Methyltransferase small domain
- Protein arginine N-methyltransferase
- S-adenosyl-L-methionine-dependent methyltransferase superfamily
- SH3-like domain superfamily
- Protein arginine N-methyltransferase domain
- SH3 domain
- Methyltransferase small domain
- Arginine methyltransferase oligomerization subdomain
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PRMT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PRMT2 as an antibody target. Whether an autoantibody or antibody against PRMT2 could matter depends on whether native PRMT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PRMT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PRMT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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