Seroatlas · Human Serome Atlas

KLF9

Krueppel-like factor 9

Also known as: BTEB1, KLF9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13886
Gene: KLF9
Ensembl: ENSG00000119138
Chromosome: 9
Canonical length: 244 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>Q13886|KLF9
     1  MSAAAYMDFV AAQCLVSISN RAAVPEHGVA PDAERLRLPE REVTKEHGDP GDTWKDYCTL
    61  VTIAKSLLDL NKYRPIQTPS VCSDSLESPD EDMGSDSDVT TESGSSPSHS PEERQDPGSA
   121  PSPLSLLHPG VAAKGKHASE KRHKCPYSGC GKVYGKSSHL KAHYRVHTGE RPFPCTWPDC
   181  LKKFSRSDEL TRHYRTHTGE KQFRCPLCEK RFMRSDHLTK HARRHTEFHP SMIKRSKKAL
   241  ANAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLF9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 115 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 115 nTPM
blood vessel: 101 nTPM
tongue: 88 nTPM
liver: 85 nTPM
adipose tissue: 77 nTPM
lung: 67 nTPM

Single-cell type

schwann cells: 580 nCPM
thymic myoid cells: 479 nCPM
platelets: 423 nCPM
pericytes: 367 nCPM
fibroblasts: 360 nCPM
vascular smooth muscle cells: 340 nCPM

Immune cell

memory B-cell: 1 nTPM
basophil: 0.7 nTPM
naive CD4 T-cell: 0.7 nTPM
MAIT T-cell: 0.6 nTPM
naive B-cell: 0.6 nTPM
T-reg: 0.6 nTPM

Brain region

cerebellum: 66 nTPM
cerebral cortex: 51 nTPM
thalamus: 51 nTPM
medulla oblongata: 50 nTPM
basal ganglia: 50 nTPM
midbrain: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.89
gnomAD missense Z: 2.27
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

circadian rhythm
negative regulation of keratinocyte proliferation
regulation of transcription by RNA polymerase II
cellular response to cortisol stimulus

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLF9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLF9 as an antibody target. Whether an autoantibody or antibody against KLF9 could matter depends on whether native KLF9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLF9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLF9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...