Seroatlas · Human Serome Atlas

CUEDC2

CUE domain-containing protein 2

Also known as: C10orf66, CUED2_HUMAN, MGC2491

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H467
Gene: CUEDC2
Ensembl: ENSG00000107874
Chromosome: 10
Canonical length: 287 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable ubiquitin binding activity. Acts upstream of or within negative regulation of cytokine production involved in inflammatory response and negative regulation of macrophage cytokine production. Located in cytosol; nuclear membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

287 residues, UniProt reviewed canonical sequence.

>Q9H467|CUEDC2
     1  MELERIVSAA LLAFVQTHLP EADLSGLDEV IFSYVLGVLE DLGPSGPSEE NFDMEAFTEM
    61  MEAYVPGFAH IPRGTIGDMM QKLSGQLSDA RNKENLQPQS SGVQGQVPIS PEPLQRPEML
   121  KEETRSSAAA AADTQDEATG AEEELLPGVD VLLEVFPTCS VEQAQWVLAK ARGDLEEAVQ
   181  MLVEGKEEGP AAWEGPNQDL PRRLRGPQKD ELKSFILQKY MMVDSAEDQK IHRPMAPKEA
   241  PKKLIRYIDN QVVSTKGERF KDVRNPEAEE MKATYINLKP ARKYRFH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CUEDC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 112 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 112 nTPM
tongue: 111 nTPM
choroid plexus: 101 nTPM
heart muscle: 92 nTPM
cerebral cortex: 88 nTPM
amygdala: 85 nTPM

Single-cell type

decidual stromal cells: 138 nCPM
hofbauer cells: 95 nCPM
epididymal principal cells: 88 nCPM
schwann cells: 84 nCPM
cytotrophoblasts: 83 nCPM
esophageal basal cells: 82 nCPM

Immune cell

myeloid DC: 112 nTPM
classical monocyte: 112 nTPM
basophil: 100 nTPM
plasmacytoid DC: 98 nTPM
NK-cell: 93 nTPM
intermediate monocyte: 92 nTPM

Brain region

cerebellum: 64 nTPM
hypothalamus: 64 nTPM
thalamus: 63 nTPM
white matter: 58 nTPM
pons: 57 nTPM
basal ganglia: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0.06
gnomAD missense Z: 1.38
DepMap mean gene effect: 0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ubiquitin system component CUE
CUE domain
CUE domain-containing protein 2, CUE domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CUEDC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CUEDC2 as an antibody target. Whether an autoantibody or antibody against CUEDC2 could matter depends on whether native CUEDC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CUEDC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CUEDC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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