Seroatlas · Human Serome Atlas

CREB1

Cyclic AMP-responsive element-binding protein 1

Also known as: CREB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P16220
Gene
CREB1
Ensembl
ENSG00000118260
Chromosome
2
Canonical length
327 aa
Protein class
Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Centrosome,Basal body

OverviewNCBI Gene

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>P16220|CREB1
     1  MTMESGAENQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA PTVTLVQLPN
    61  GQTVQVHGVI QAAQPSVIQS PQVQTVQIST IAESEDSQES VDSVTDSQKR REILSRRPSY
   121  RKILNDLSSD APGVPRIEEE KSEEETSAPA ITTVTVPTPI YQTSSGQYIA ITQGGAIQLA
   181  NNGTDGVQGL QTLTMTNAAA TQPGTTILQY AQTTDGQQIL VPSNQVVVQA ASGDVQTYQI
   241  RTAPTSTIAP GVVMASSPAL PTQPAEEAAR KREVRLMKNR EAARECRRKK KEYVKCLENR
   301  VAVLENQNKT LIEELKALKD LYCHKSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CREB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • testis: 30 nTPM
  • thymus: 27 nTPM
  • tonsil: 23 nTPM
  • bone marrow: 21 nTPM
  • lymph node: 21 nTPM
  • thyroid gland: 17 nTPM

Single-cell type

  • early spermatids: 621 nCPM
  • neutrophils: 618 nCPM
  • neutrophil progenitors: 248 nCPM
  • innate lymphoid cells: 224 nCPM
  • cardiomyocytes: 196 nCPM
  • monocyte progenitors: 189 nCPM

Immune cell

  • neutrophil: 57 nTPM
  • NK-cell: 46 nTPM
  • T-reg: 39 nTPM
  • memory B-cell: 37 nTPM
  • non-classical monocyte: 35 nTPM
  • naive B-cell: 35 nTPM

Brain region

  • cerebellum: 50 nTPM
  • white matter: 44 nTPM
  • choroid plexus: 39 nTPM
  • cerebral cortex: 37 nTPM
  • hypothalamus: 37 nTPM
  • basal ganglia: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CREB1.

Disease | AllUniProt

Conditions CREB1 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
1
gnomAD missense Z
2.91
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CREB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CREB1 as an antibody target. Whether an autoantibody or antibody against CREB1 could matter depends on whether native CREB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CREB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CREB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CREB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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