Pentatricopeptide repeat
IPR002885
Definition
This entry represents the PPR repeat. Pentatricopeptide repeat (PPR) proteins are characterised by tandem repeats of a degenerate 35 amino acid motif PMID:10664580. PPR proteins are sequence-specific RNA-binding proteins that are involved in multiple aspects of RNA metabolism [[cite:PMID:18031283], [cite:PMID:22576772]]. They can bind a diversity of sequences that confers the variability in its functions PMID:30125002. Most have roles in mitochondria or plastids PMID:15270678. PPR repeats were discovered while screening Arabidopsis proteins for those predicted to be targeted to mitochondria or chloroplast [[cite:PMID:10664580], [cite:PMID:15269332]]. Some of these proteins have been shown to play a role in post-transcriptional processes within organelles [[cite:PMID:12782738], [cite:PMID:12832482]]. Plant genomes have between one hundred to five hundred PPR genes per genome whereas non-plant genomes encode two to six PPR proteins. The plant PPR protein family has been divided in two subfamilies on the basis of their motif content and organisation [[cite:PMID:15269332], [cite:PMID:17560114]]. The crystal structure of maize chloroplast PPR10 has been reported. The nineteen repeats of PPR10 are assembled into a right-handed superhelical spiral. PPR10 forms a homodimer and exhibits considerable conformational changes upon binding to its ssRNA target, with six nucleotides being specifically recognised by six corresponding PPR10 repeats PMID:24162847.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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