Seroatlas · Human Serome Atlas

MRPL32

Large ribosomal subunit protein bL32m

Also known as: bMRP-59b, HSPC283, L32mt, MRP-L32, RM32_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BYC8
Gene: MRPL32
Ensembl: ENSG00000106591
Chromosome: 7
Canonical length: 188 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L32 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome Xp. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>Q9BYC8|MRPL32
     1  MALAMLVLVV SPWSAARGVL RNYWERLLRK LPQSRPGFPS PPWGPALAVQ GPAMFTEPAN
    61  DTSGSKENSS LLDSIFWMAA PKNRRTIEVN RCRRRNPQKL IKVKNNIDVC PECGHLKQKH
   121  VLCAYCYEKV CKETAEIRRQ IGKQEGGPFK APTIETVVLY TGETPSEQDQ GKRIIERDRK
   181  RPSWFTQN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 112 nTPM

Expression across tissuesHPA

Tissue

liver: 112 nTPM
heart muscle: 79 nTPM
choroid plexus: 79 nTPM
kidney: 77 nTPM
adrenal gland: 73 nTPM
ovary: 64 nTPM

Single-cell type

esophageal basal cells: 180 nCPM
oocytes: 161 nCPM
gastric progenitor cells: 155 nCPM
esophageal suprabasal cells: 155 nCPM
migrating cytotrophoblasts: 139 nCPM
cytotrophoblasts: 131 nCPM

Immune cell

basophil: 183 nTPM
T-reg: 161 nTPM
memory B-cell: 155 nTPM
eosinophil: 148 nTPM
naive B-cell: 124 nTPM
naive CD4 T-cell: 121 nTPM

Brain region

choroid plexus: 42 nTPM
hypothalamus: 29 nTPM
cerebral cortex: 28 nTPM
white matter: 24 nTPM
basal ganglia: 23 nTPM
medulla oblongata: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: -0.05
DepMap mean gene effect: -0.53
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc-binding ribosomal protein
Large ribosomal subunit protein bL32
Mitochondrial ribosomal protein bL32
Ribosomal L32p protein family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPL32 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL32 as an antibody target. Whether an autoantibody or antibody against MRPL32 could matter depends on whether native MRPL32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL32 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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