Seroatlas · Human Serome Atlas

MRPL14

Large ribosomal subunit protein uL14m

Also known as: MRP-L32, RM14_HUMAN, RPML32

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P1L8
Gene: MRPL14
Ensembl: ENSG00000180992
Chromosome: 6
Canonical length: 145 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

This nuclear gene encodes a protein component of the 39S subunit of the mitochondrial ribosome. A pseudogene of this gene is found on chromosome 17. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

145 residues, UniProt reviewed canonical sequence.

>Q6P1L8|MRPL14
     1  MAFFTGLWGP FTCVSRVLSH HCFSTTGSLS AIQKMTRVRV VDNSALGNSP YHRAPRCIHV
    61  YKKNGVGKVG DQILLAIKGQ KKKALIVGHC MPGPRMTPRF DSNNVVLIED NGNPVGTRIK
   121  TPIPTSLRKR EGEYSKVLAI AQNFV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 176 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 176 nTPM
tongue: 102 nTPM
liver: 77 nTPM
lung: 56 nTPM
testis: 50 nTPM
heart muscle: 46 nTPM

Single-cell type

alveolar cells type 2: 538 nCPM
hofbauer cells: 476 nCPM
alveolar cells type 1: 435 nCPM
late primary spermatocytes: 427 nCPM
transitional alveolar cells: 424 nCPM
hepatocytes: 414 nCPM

Immune cell

NK-cell: 172 nTPM
plasmacytoid DC: 123 nTPM
classical monocyte: 116 nTPM
intermediate monocyte: 114 nTPM
memory B-cell: 112 nTPM
myeloid DC: 109 nTPM

Brain region

white matter: 20 nTPM
thalamus: 20 nTPM
basal ganglia: 19 nTPM
spinal cord: 18 nTPM
hippocampal formation: 18 nTPM
amygdala: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: -0.31
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial translation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPL14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL14 as an antibody target. Whether an autoantibody or antibody against MRPL14 could matter depends on whether native MRPL14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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