IP6K2

Protein identityUniProt · HPA

UniProt accession

Q9UHH9

Gene

IP6K2

Ensembl

ENSG00000068745

Chromosome

3

Canonical length

426 aa

Protein class

Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli fibrillar center,Cell Junctions

OverviewNCBI Gene

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

426 residues, UniProt reviewed canonical sequence.

>Q9UHH9|IP6K2
     1  MSPAFRAMDV EPRAKGVLLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ FYETLPAEMR
    61  KFTPQYKGVV SVRFEEDEDR NLCLIAYPLK GDHGIVDIVD NSDCEPKSKL LRWTTNKKHH
   121  VLETEKTPKD WVRQHRKEEK MKSHKLEEEF EWLKKSEVLY YTVEKKGNIS SQLKHYNPWS
   181  MKCHQQQLQR MKENAKHRNQ YKFILLENLT SRYEVPCVLD LKMGTRQHGD DASEEKAANQ
   241  IRKCQQSTSA VIGVRVCGMQ VYQAGSGQLM FMNKYHGRKL SVQGFKEALF QFFHNGRYLR
   301  RELLGPVLKK LTELKAVLER QESYRFYSSS LLVIYDGKER PEVVLDSDAE DLEDLSEESA
   361  DESAGAYAYK PIGASSVDVR MIDFAHTTCR LYGEDTVVHE GQDAGYIFGL QSLIDIVTEI
   421  SEESGE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IP6K2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

166 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.32

gnomAD pLI

0.97

gnomAD missense Z

2.63

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• inositol phosphate biosynthetic process
• inositol phosphate metabolic process
• negative regulation of cell growth
• phosphatidylinositol phosphate biosynthetic process
• positive regulation of apoptotic process
• positive regulation of protein K48-linked ubiquitination
• protein stabilization
• cellular response to flavonoid

Molecular functions

• ATP binding
• diphosphoinositol pentakisphosphate kinase activity
• diphosphoinositol tetrakisphosphate kinase activity
• flavonoid binding
• inositol 5-diphosphate pentakisphosphate 5-kinase activity
• inositol hexakisphosphate 5-kinase activity
• inositol hexakisphosphate kinase activity
• inositol-1,3,4,5,6-pentakisphosphate kinase activity
• protein-containing complex binding

Cellular components

• cell junction
• cytoplasm
• fibrillar center
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Inositol polyphosphate kinase
• Inositol polyphosphate kinase superfamily
• Inositol polyphosphate kinase

KeywordsUniProt

• ATP-binding
• Kinase
• Lipid metabolism
• Nucleotide-binding
• Nucleus
• Phospholipid metabolism
• Transferase

InteractionsUniProt · HPA

Protein binding partners of IP6K2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HSP90AA1
• LNX2