Seroatlas · Human Serome Atlas

SCLY

Selenocysteine lyase

Also known as: SCL, SCLY_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96I15
Gene
SCLY
Ensembl
ENSG00000132330
Chromosome
2
Canonical length
445 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus
Quaternary structure
Homodimer

OverviewNCBI Gene

Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

445 residues, UniProt reviewed canonical sequence.

>Q96I15|SCLY
     1  MEAAVAPGRD APAPAASQPS GCGKHNSPER KVYMDYNATT PLEPEVIQAM TKAMWEAWGN
    61  PSSPYSAGRK AKDIINAARE SLAKMIGGKP QDIIFTSGGT ESNNLVIHSV VKHFHANQTS
   121  KGHTGGHHSP VKGAKPHFIT SSVEHDSIRL PLEHLVEEQV AAVTFVPVSK VSGQAEVDDI
   181  LAAVRPTTRL VTIMLANNET GIVMPVPEIS QRIKALNQER VAAGLPPILV HTDAAQALGK
   241  QRVDVEDLGV DFLTIVGHKF YGPRIGALYI RGLGEFTPLY PMLFGGGQER NFRPGTENTP
   301  MIAGLGKAAE LVTQNCEAYE AHMRDVRDYL EERLEAEFGQ KRIHLNSQFP GTQRLPNTCN
   361  FSIRGPRLQG HVVLAQCRVL MASVGAACHS DHGDQPSPVL LSYGVPFDVA RNALRLSVGR
   421  STTRAEVDLV VQDLKQAVAQ LEDQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SCLY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • liver: 38 nTPM
  • pancreas: 22 nTPM
  • testis: 16 nTPM
  • cerebellum: 13 nTPM
  • kidney: 13 nTPM
  • spinal cord: 10 nTPM

Single-cell type

  • late spermatids: 87 nCPM
  • oligodendrocytes: 54 nCPM
  • early spermatids: 45 nCPM
  • choroid plexus epithelial cells: 40 nCPM
  • oligodendrocyte progenitor cells: 36 nCPM
  • microglia: 36 nCPM

Immune cell

  • memory CD8 T-cell: 4.4 nTPM
  • eosinophil: 4 nTPM
  • non-classical monocyte: 3.5 nTPM
  • myeloid DC: 3.3 nTPM
  • classical monocyte: 3.2 nTPM
  • T-reg: 3.2 nTPM

Brain region

  • white matter: 14 nTPM
  • pons: 13 nTPM
  • cerebellum: 13 nTPM
  • medulla oblongata: 12 nTPM
  • basal ganglia: 12 nTPM
  • midbrain: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.15
gnomAD pLI
0
gnomAD missense Z
-0.09
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SCLY in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SCLY as an antibody target. Whether an autoantibody or antibody against SCLY could matter depends on whether native SCLY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SCLY is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SCLY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SCLY. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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