PDZ domain-containing scaffold protein
IPR051342
Definition
This family of proteins includes scaffolding proteins that play key roles in cellular signaling, localization, and structural integrity. They are involved in the formation and maintenance of tight junctions and epithelial cell polarity. Some family members act as E3 ubiquitin-protein ligases, mediating ubiquitination and degradation of specific substrates. Others are implicated in synaptic plasticity, participating in NMDAR signaling complexes that may control AMPAR potentiation. These proteins often contain PDZ domains that mediate interactions with various partners, influencing processes such as vesicle transport, cell migration, and the organization of multiprotein complexes. The family also includes proteins that regulate the feedback of phototransduction in photoreceptors and proteins that may affect the surface expression and function of ion channels in sensory neurons.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...