NMD3

Protein identityUniProt · HPA

UniProt accession

Q96D46

Gene

NMD3

Ensembl

ENSG00000169251

Chromosome

3

Canonical length

503 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli

OverviewNCBI Gene

Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the cytoplasm. Several transcript variants exist for this gene, but the full-length natures of only two have been described to date. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

503 residues, UniProt reviewed canonical sequence.

>Q96D46|NMD3
     1  MEYMAESTDR SPGHILCCEC GVPISPNPAN ICVACLRSKV DISQGIPKQV SISFCKQCQR
    61  YFQPPGTWIQ CALESRELLA LCLKKIKAPL SKVRLVDAGF VWTEPHSKRL KVKLTIQKEV
   121  MNGAILQQVF VVDYVVQSQM CGDCHRVEAK DFWKAVIQVR QKTLHKKTFY YLEQLILKYG
   181  MHQNTLRIKE IHDGLDFYYS SKQHAQKMVE FLQCTVPCRY KASQRLISQD IHSNTYNYKS
   241  TFSVEIVPIC KDNVVCLSPK LAQSLGNMNQ ICVCIRVTSA IHLIDPNTLQ VADIDGSTFW
   301  SHPFNSLCHP KQLEEFIVME CSIVQDIKRA AGAGMISKKH TLGEVWVQKT SEMNTDKQYF
   361  CRTHLGHLLN PGDLVLGFDL ANCNLNDEHV NKMNSDRVPD VVLIKKSYDR TKRQRRRNWK
   421  LKELAREREN MDTDDERQYQ DFLEDLEEDE AIRKNVNIYR DSAIPVESDT DDEGAPRISL
   481  AEMLEDLHIS QDATGEEGAS MLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NMD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

73 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.82

gnomAD pLI

0

gnomAD missense Z

0.19

DepMap mean gene effect

-1.16

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• positive regulation of protein localization to nucleolus
• positive regulation of RNA biosynthetic process
• protein transport
• ribosomal large subunit export from nucleus

Molecular functions

• protein-macromolecule adaptor activity
• ribosomal large subunit binding
• RNA binding

Cellular components

• cytoplasm
• membrane
• nucleolus
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Nmd3, N-terminal
• Ribosomal export protein Nmd3
• 60S ribosomal export protein NMD3, OB-fold domain
• 60S ribosomal export protein NMD3, SH3 domain
• NMD3 family
• NMD3 OB-fold domain
• NMD3 SH3 domain

KeywordsUniProt

• Acetylation
• Cytoplasm
• Nucleus
• Phosphoprotein
• Protein transport
• Transport

InteractionsUniProt · HPA

Protein binding partners of NMD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• XPO1
• LNX2