Interferon regulatory factor, conserved site

Definition

The expression of type I interferon genes (interferons alpha and beta) is induced by many agents, including viral attack PMID:3409321. Induction is mediated by the binding of interferon regulatory factor 1 (IRF-1) to a region known as the interferon consensus sequence (ICS), located upstream of the interferon genes PMID:1460054. Other factors may also bind to the ICS, including IRF-2, which does not function as an activator, but rather suppresses the function of IRF-1 under certain circumstances PMID:2475256. IRF proteins contain a conserved N-terminal DNA-binding region of about 120 amino acids, which folds into a structure that binds specifically to the ICS; the remaining parts of the sequences vary depending on the precise function of the protein PMID:1460054. This region contains five conserved tryptophans and is known as a 'tryptophan pentad repeat'.

9 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (9 proteins: gene, accession, name)

• IRF1
• IRF2
• IRF3
• IRF4
• IRF5
• IRF6
• IRF7
• IRF8
• IRF9