Seroatlas · Human Serome Atlas

TRMT61B

tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial

Also known as: FLJ20628, TR61B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BVS5
Gene
TRMT61B
Ensembl
ENSG00000171103
Chromosome
2
Canonical length
477 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homooligomer

OverviewNCBI Gene

Enables mRNA (adenine-N1-)-methyltransferase activity; rRNA (adenine) methyltransferase activity; and tRNA (adenine(58)-N1)-methyltransferase activity. Involved in mRNA processing and mitochondrial tRNA processing. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

477 residues, UniProt reviewed canonical sequence.

>Q9BVS5|TRMT61B
     1  MLMAWCRGPV LLCLRQGLGT NSFLHGLGQE PFEGARSLCC RSSPRDLRDG EREHEAAQRK
    61  APGAESCPSL PLSISDIGTG CLSSLENLRL PTLREESSPR ELEDSSGDQG RCGPTHQGSE
   121  DPSMLSQAQS ATEVEERHVS PSCSTSRERP FQAGELILAE TGEGETKFKK LFRLNNFGLL
   181  NSNWGAVPFG KIVGKFPGQI LRSSFGKQYM LRRPALEDYV VLMKRGTAIT FPKDINMILS
   241  MMDINPGDTV LEAGSGSGGM SLFLSKAVGS QGRVISFEVR KDHHDLAKKN YKHWRDSWKL
   301  SHVEEWPDNV DFIHKDISGA TEDIKSLTFD AVALDMLNPH VTLPVFYPHL KHGGVCAVYV
   361  VNITQVIELL DGIRTCELAL SCEKISEVIV RDWLVCLAKQ KNGILAQKVE SKINTDVQLD
   421  SQEKIGVKGE LFQEDDHEES HSDFPYGSFP YVARPVHWQP GHTAFLVKLR KVKPQLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRMT61B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 16 nTPM
  • heart muscle: 14 nTPM
  • cerebellum: 14 nTPM
  • parathyroid gland: 14 nTPM
  • kidney: 13 nTPM
  • duodenum: 13 nTPM

Single-cell type

  • rod photoreceptor cells: 80 nCPM
  • myonuclei: 57 nCPM
  • brain inhibitory neurons: 54 nCPM
  • cone photoreceptor cells: 52 nCPM
  • brain excitatory neurons: 51 nCPM
  • hematopoietic stem cells: 43 nCPM

Immune cell

  • NK-cell: 18 nTPM
  • T-reg: 15 nTPM
  • memory B-cell: 15 nTPM
  • naive B-cell: 14 nTPM
  • MAIT T-cell: 14 nTPM
  • naive CD4 T-cell: 14 nTPM

Brain region

  • cerebellum: 14 nTPM
  • choroid plexus: 14 nTPM
  • white matter: 11 nTPM
  • cerebral cortex: 11 nTPM
  • pons: 9.8 nTPM
  • hypothalamus: 9.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
gnomAD missense Z
-0.64
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRMT61B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRMT61B as an antibody target. Whether an autoantibody or antibody against TRMT61B could matter depends on whether native TRMT61B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRMT61B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRMT61B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRMT61B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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