Seroatlas · Human Serome Atlas

PALD1

Paladin

Also known as: KIAA1274, PALD, PALD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULE6
Gene: PALD1
Ensembl: ENSG00000107719
Chromosome: 10
Canonical length: 856 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable protein tyrosine phosphatase activity. Located in cytosol and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

856 residues, UniProt reviewed canonical sequence.

>Q9ULE6|PALD1
     1  MGTTASTAQQ TVSAGTPFEG LQGSGTMDSR HSVSIHSFQS TSLHNSKAKS IIPNKVAPVV
    61  ITYNCKEEFQ IHDELLKAHY TLGRLSDNTP EHYLVQGRYF LVRDVTEKMD VLGTVGSCGA
   121  PNFRQVQGGL TVFGMGQPSL SGFRRVLQKL QKDGHRECVI FCVREEPVLF LRADEDFVSY
   181  TPRDKQNLHE NLQGLGPGVR VESLELAIRK EIHDFAQLSE NTYHVYHNTE DLWGEPHAVA
   241  IHGEDDLHVT EEVYKRPLFL QPTYRYHRLP LPEQGSPLEA QLDAFVSVLR ETPSLLQLRD
   301  AHGPPPALVF SCQMGVGRTN LGMVLGTLIL LHRSGTTSQP EAAPTQAKPL PMEQFQVIQS
   361  FLRMVPQGRR MVEEVDRAIT ACAELHDLKE VVLENQKKLE GIRPESPAQG SGSRHSVWQR
   421  ALWSLERYFY LILFNYYLHE QYPLAFALSF SRWLCAHPEL YRLPVTLSSA GPVAPRDLIA
   481  RGSLREDDLV SPDALSTVRE MDVANFRRVP RMPIYGTAQP SAKALGSILA YLTDAKRRLR
   541  KVVWVSLREE AVLECDGHTY SLRWPGPPVA PDQLETLEAQ LKAHLSEPPP GKEGPLTYRF
   601  QTCLTMQEVF SQHRRACPGL TYHRIPMPDF CAPREEDFDQ LLEALRAALS KDPGTGFVFS
   661  CLSGQGRTTT AMVVAVLAFW HIQGFPEVGE EELVSVPDAK FTKGEFQVVM KVVQLLPDGH
   721  RVKKEVDAAL DTVSETMTPM HYHLREIIIC TYRQAKAAKE AQEMRRLQLR SLQYLERYVC
   781  LILFNAYLHL EKADSWQRPF STWMQEVASK AGIYEILNEL GFPELESGED QPFSRLRYRW
   841  QEQSCSLEPS APEDLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PALD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

lung: 19 nTPM
spleen: 14 nTPM
colon: 14 nTPM
spinal cord: 13 nTPM
midbrain: 12 nTPM
basal ganglia: 10 nTPM

Single-cell type

microglia: 581 nCPM
nk-cells: 247 nCPM
lymphatic endothelial cells: 177 nCPM
pdcs: 171 nCPM
macrophages: 121 nCPM
vascular endothelial cells: 66 nCPM

Immune cell

plasmacytoid DC: 2.6 nTPM
gdT-cell: 1.1 nTPM
NK-cell: 0.8 nTPM
total PBMC: 0.8 nTPM
MAIT T-cell: 0.7 nTPM
memory CD8 T-cell: 0.6 nTPM

Brain region

medulla oblongata: 23 nTPM
spinal cord: 23 nTPM
thalamus: 21 nTPM
pons: 19 nTPM
white matter: 18 nTPM
midbrain: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0
gnomAD missense Z: 0.83
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

protein tyrosine phosphatase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PALD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

IRF7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PALD1 as an antibody target. Whether an autoantibody or antibody against PALD1 could matter depends on whether native PALD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PALD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PALD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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