Seroatlas · Human Serome Atlas

LTN1

E3 ubiquitin-protein ligase listerin

Also known as: C21orf10, C21orf98, FLJ11053, KIAA0714, LISTERIN, LTN1_HUMAN, RNF160, ZNF294

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94822
Gene: LTN1
Ensembl: ENSG00000198862
Chromosome: 21
Canonical length: 1766 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

1766 residues, UniProt reviewed canonical sequence.

>O94822|LTN1
     1  MGGKNKQRTK GNLRPSNSGR AAELLAKEQG TVPGFIGFGT SQSDLGYVPA IQGAEEIDSL
    61  VDSDFRMVLR KLSKKDVTTK LKAMQEFGTM CTERDTETVK GVLPYWPRIF CKISLDHDRR
   121  VREATQQAFE KLILKVKKQL APYLKSLMGY WLMAQCDTYT PAAFAAKDAF EAAFPPSKQP
   181  EAIAFCKDEI TSVLQDHLIK ETPDTLSDPQ TVPEEEREAK FYRVVTCSLL ALKRLLCLLP
   241  DNELDSLEEK FKSLLSQNKF WKYGKHSVPQ IRSAYFELVS ALCQRIPQLM KEEASKVSPS
   301  VLLSIDDSDP IVCPALWEAV LYTLTTIEDC WLHVNAKKSV FPKLSTVIRE GGRGLATVIY
   361  PYLLPFISKL PQSITNPKLD FFKNFLTSLV AGLSTERTKT SSLESSAVIS AFFECLRFIM
   421  QQNLGEEEIE QMLVNDQLIP FIDAVLKDPG LQHGQLFNHL AETLSSWEAK ADTEKDEKTA
   481  HNLENVLIHF WERLSEICVA KISEPEADVE SVLGVSNLLQ VLQKPKSSLK SSKKKNGKVR
   541  FADEILESNK ENEKCVSSEG EKIEGWELTT EPSLTHNSSG LLSPLRKKPL EDLVCKLADI
   601  SINYVNERKS EQHLRFLSTL LDSFSSSRVF KMLLGDEKQS IVQAKPLEIA KLVQKNPAVQ
   661  FLYQKLIGWL NEDQRKDFGF LVDILYSALR CCDNDMERKK VLDDLTKVDL KWNSLLKIIE
   721  KACPSSDKHA LVTPWLKGDI LGEKLVNLAD CLCNEDLESR VSSESHFSER WTLLSLVLSQ
   781  HVKNDYLIGD VYVERIIVRL HETLFKTKKL SEAESSDSSV SFICDVAYNY FSSAKGCLLM
   841  PSSEDLLLTL FQLCAQSKEK THLPDFLICK LKNTWLSGVN LLVHQTDSSY KESTFLHLSA
   901  LWLKNQVQAS SLDINSLQVL LSAVDDLLNT LLESEDSYLM GVYIGSVMPN DSEWEKMRQS
   961  LPMQWLHRPL LEGRLSLNYE CFKTDFKEQD IKTLPSHLCT SALLSKMVLI ALRKETVLEN
  1021  NELEKIIAEL LYSLQWCEEL DNPPIFLIGF CEILQKMNIT YDNLRVLGNT SGLLQLLFNR
  1081  SREHGTLWSL IIAKLILSRS ISSDEVKPHY KRKESFFPLT EGNLHTIQSL CPFLSKEEKK
  1141  EFSAQCIPAL LGWTKKDLCS TNGGFGHLAI FNSCLQTKSI DDGELLHGIL KIIISWKKEH
  1201  EDIFLFSCNL SEASPEVLGV NIEIIRFLSL FLKYCSSPLA ESEWDFIMCS MLAWLETTSE
  1261  NQALYSIPLV QLFACVSCDL ACDLSAFFDS TTLDTIGNLP VNLISEWKEF FSQGIHSLLL
  1321  PILVTVTGEN KDVSETSFQN AMLKPMCETL TYISKEQLLS HKLPARLVAD QKTNLPEYLQ
  1381  TLLNTLAPLL LFRARPVQIA VYHMLYKLMP ELPQYDQDNL KSYGDEEEEP ALSPPAALMS
  1441  LLSIQEDLLE NVLGCIPVGQ IVTIKPLSED FCYVLGYLLT WKLILTFFKA ASSQLRALYS
  1501  MYLRKTKSLN KLLYHLFRLM PENPTYAETA VEVPNKDPKT FFTEELQLSI RETTMLPYHI
  1561  PHLACSVYHM TLKDLPAMVR LWWNSSEKRV FNIVDRFTSK YVSSVLSFQE ISSVQTSTQL
  1621  FNGMTVKARA TTREVMATYT IEDIVIELII QLPSNYPLGS IIVESGKRVG VAVQQWRNWM
  1681  LQLSTYLTHQ NGSIMEGLAL WKNNVDKRFE GVEDCMICFS VIHGFNYSLP KKACRTCKKK
  1741  FHSACLYKWF TSSNKSTCPL CRETFF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LTN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

placenta: 18 nTPM
bone marrow: 16 nTPM
testis: 13 nTPM
prostate: 12 nTPM
breast: 12 nTPM
thyroid gland: 11 nTPM

Single-cell type

early spermatids: 327 nCPM
neutrophil progenitors: 112 nCPM
erythrocyte progenitors: 110 nCPM
prostatic glandular cells: 101 nCPM
oligodendrocytes: 93 nCPM
neutrophils: 91 nCPM

Immune cell

basophil: 13 nTPM
non-classical monocyte: 11 nTPM
neutrophil: 8.6 nTPM
eosinophil: 7.9 nTPM
intermediate monocyte: 7.6 nTPM
NK-cell: 7 nTPM

Brain region

white matter: 36 nTPM
basal ganglia: 26 nTPM
cerebellum: 24 nTPM
medulla oblongata: 24 nTPM
hypothalamus: 24 nTPM
pons: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.01
gnomAD missense Z: 1.9
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, RING-type
Zinc finger, RING-CH-type
Armadillo-like helical
Zinc finger, RING/FYVE/PHD-type
Armadillo-type fold
E3 ubiquitin-protein ligase listerin
Listerin, zinc finger, RING-type
E3 ubiquitin-protein ligase listerin, N-terminal domain
E3 ubiquitin-protein ligase listerin, HEAT repeat region
E3 ubiquitin-protein ligase listerin, ubiquitin conjugating domain
E3 ubiquitin-protein ligase listerin, HEAT-repeats region
E3 ubiquitin-protein ligase listerin, N-terminal domain
LTN1 family HEAT repeat region
Ubiquitin conjugating domain-like
Listerin HEAT repeat region

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LTN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LTN1 as an antibody target. Whether an autoantibody or antibody against LTN1 could matter depends on whether native LTN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LTN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LTN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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