Seroatlas · Human Serome Atlas

INCA1

Protein INCA1

Also known as: INCA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0VD86
Gene: INCA1
Ensembl: ENSG00000196388
Chromosome: 17
Canonical length: 236 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and identical protein binding activity. Acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

236 residues, UniProt reviewed canonical sequence.

>Q0VD86|INCA1
     1  MQVQDDGVNL IPFAKCSRVV SRSPPPRLPS QSLRPMPQRY GDVFWKNLNQ RPTPTWLEEQ
    61  HIPPMLRATG CSQLGLYPPE QLPPPEMLWR RKKRRPCLEG MQQQGLGGVP ARVRAVTYHL
   121  EDLRRRQSII NELKKAQWGS SGAASEPVVL GEEGCGFPST NEYPDLEEER ATYPQEEDRF
   181  LTPGRAQLLW SPWSPLDQEE ACASRQLHSL ASFSTVTARR NPLHNPWGME LAASEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INCA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

testis: 46 nTPM
duodenum: 10 nTPM
skeletal muscle: 10 nTPM
lymph node: 8 nTPM
skin: 7.4 nTPM
thyroid gland: 7.4 nTPM

Single-cell type

late spermatids: 513 nCPM
early primary spermatocytes: 254 nCPM
early spermatids: 122 nCPM
late primary spermatocytes: 88 nCPM
undifferentiated spermatogonia: 39 nCPM
differentiating spermatogonia: 18 nCPM

Immune cell

intermediate monocyte: 1.6 nTPM
non-classical monocyte: 1.3 nTPM
classical monocyte: 0.9 nTPM
MAIT T-cell: 0.7 nTPM
naive CD4 T-cell: 0.7 nTPM
naive CD8 T-cell: 0.6 nTPM

Brain region

pons: 15 nTPM
cerebellum: 15 nTPM
thalamus: 14 nTPM
medulla oblongata: 14 nTPM
white matter: 14 nTPM
hypothalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.8
gnomAD pLI: 0
gnomAD missense Z: 0.23
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein INCA1
INCA1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INCA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INCA1 as an antibody target. Whether an autoantibody or antibody against INCA1 could matter depends on whether native INCA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INCA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INCA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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