Seroatlas · Human Serome Atlas

ING5

Inhibitor of growth protein 5

Also known as: FLJ23842, ING5_HUMAN, p28ING5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WYH8
Gene: ING5
Ensembl: ENSG00000168395
Chromosome: 2
Canonical length: 240 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

240 residues, UniProt reviewed canonical sequence.

>Q8WYH8|ING5
     1  MATAMYLEHY LDSIENLPCE LQRNFQLMRE LDQRTEDKKA EIDILAAEYI STVKTLSPDQ
    61  RVERLQKIQN AYSKCKEYSD DKVQLAMQTY EMVDKHIRRL DADLARFEAD LKDKMEGSDF
   121  ESSGGRGLKK GRGQKEKRGS RGRGRRTSEE DTPKKKKHKG GSEFTDTILS VHPSDVLDMP
   181  VDPNEPTYCL CHQVSYGEMI GCDNPDCPIE WFHFACVDLT TKPKGKWFCP RCVQEKRKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ING5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 26 nTPM
ovary: 24 nTPM
pituitary gland: 23 nTPM
pancreas: 23 nTPM
thyroid gland: 22 nTPM
prostate: 21 nTPM

Single-cell type

cardiomyocytes: 95 nCPM
epicardial cells: 80 nCPM
adipocytes: 79 nCPM
epididymal principal cells: 76 nCPM
myonuclei: 68 nCPM
lactotrophs: 63 nCPM

Immune cell

basophil: 21 nTPM
eosinophil: 8.8 nTPM
T-reg: 5.8 nTPM
naive CD4 T-cell: 4.6 nTPM
memory CD4 T-cell: 4.2 nTPM
classical monocyte: 4 nTPM

Brain region

cerebellum: 45 nTPM
cerebral cortex: 40 nTPM
white matter: 39 nTPM
hypothalamus: 38 nTPM
basal ganglia: 37 nTPM
hippocampal formation: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.62
gnomAD missense Z: 1.92
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ING5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ING5 as an antibody target. Whether an autoantibody or antibody against ING5 could matter depends on whether native ING5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ING5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ING5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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