Seroatlas · Human Serome Atlas

ZNF16

Zinc finger protein 16

Also known as: KOX9, ZNF16_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P17020
Gene: ZNF16
Ensembl: ENSG00000170631
Chromosome: 8
Canonical length: 682 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

The protein encoded by this gene contains multiple tandem zinc finger motifs. The encoded protein is involved in the differentiation of erythroid and megakaryocytic cells. This gene is located in a cluster of related genes on chromosome 8 encoding zinc finger proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

Canonical amino-acid sequenceUniProt

682 residues, UniProt reviewed canonical sequence.

>P17020|ZNF16
     1  MPSLRTRREE AEMELSVPGP SPWTPAAQAR VRDAPAVTHP GSAACGTPCC SDTELEAICP
    61  HYQQPDCDTR TEDKEFLHKE DIHEDLESQA EISENYAGDV SQVPELGDLC DDVSERDWGV
   121  PEGRRLPQSL SQEGDFTPAA MGLLRGPLGE KDLDCNGFDS RFSLSPNLMA CQEIPTEERP
   181  HPYDMGGQSF QHSVDLTGHE GVPTAESPLI CNECGKTFQG NPDLIQRQIV HTGEASFMCD
   241  DCGKTFSQNS VLKNRHRSHM SEKAYQCSEC GKAFRGHSDF SRHQSHHSSE RPYMCNECGK
   301  AFSQNSSLKK HQKSHMSEKP YECNECGKAF RRSSNLIQHQ RIHSGEKPYV CSECGKAFRR
   361  SSNLIKHHRT HTGEKPFECG ECGKAFSQSA HLRKHQRVHT GEKPYECNDC GKPFSRVSNL
   421  IKHHRVHTGE KPYKCSDCGK AFSQSSSLIQ HRRIHTGEKP HVCNVCGKAF SYSSVLRKHQ
   481  IIHTGEKPYR CSVCGKAFSH SSALIQHQGV HTGDKPYACH ECGKTFGRSS NLILHQRVHT
   541  GEKPYECTEC GKTFSQSSTL IQHQRIHNGL KPHECNQCGK AFNRSSNLIH HQKVHTGEKP
   601  YTCVECGKGF SQSSHLIQHQ IIHTGERPYK CSECGKAFSQ RSVLIQHQRI HTGVKPYDCA
   661  ACGKAFSQRS KLIKHQLIHT RE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

ovary: 10 nTPM
skin: 8.9 nTPM
parathyroid gland: 8.1 nTPM
skeletal muscle: 7.8 nTPM
tongue: 7.8 nTPM
pancreas: 7.1 nTPM

Single-cell type

podocytes: 38 nCPM
undifferentiated spermatogonia: 31 nCPM
proximal tubule cells: 28 nCPM
esophageal apical cells: 26 nCPM
myonuclei: 24 nCPM
rod photoreceptor cells: 22 nCPM

Immune cell

NK-cell: 9.3 nTPM
T-reg: 5.8 nTPM
MAIT T-cell: 5.6 nTPM
gdT-cell: 4.9 nTPM
myeloid DC: 4.8 nTPM
memory CD8 T-cell: 4.5 nTPM

Brain region

choroid plexus: 12 nTPM
hypothalamus: 8.6 nTPM
cerebral cortex: 8.3 nTPM
spinal cord: 8.3 nTPM
amygdala: 8 nTPM
basal ganglia: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 0.12
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell division
negative regulation of apoptotic process
positive regulation of cell division
positive regulation of cell population proliferation
positive regulation of erythrocyte differentiation
positive regulation of kinase activity
positive regulation of megakaryocyte differentiation
regulation of transcription by RNA polymerase II
cellular response to sodium dodecyl sulfate
positive regulation of cell cycle phase transition

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

INCA1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF16 as an antibody target. Whether an autoantibody or antibody against ZNF16 could matter depends on whether native ZNF16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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