Seroatlas · Human Serome Atlas

CABP5

Calcium-binding protein 5

Also known as: CABP3, CABP5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NP86
Gene: CABP5
Ensembl: ENSG00000105507
Chromosome: 19
Canonical length: 173 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The product of this gene belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of this gene is retina-specific. The mouse homolog of this protein has been shown to express in the inner nuclear layer of the retina, suggested its role in neuronal functioning. The specific function of this gene is unknown. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

173 residues, UniProt reviewed canonical sequence.

>Q9NP86|CABP5
     1  MQFPMGPACI FLRKGIAEKQ RERPLGQDEI EELREAFLEF DKDRDGFISC KDLGNLMRTM
    61  GYMPTEMELI ELGQQIRMNL GGRVDFDDFV ELMTPKLLAE TAGMIGVQEM RDAFKEFDTN
   121  GDGEITLVEL QQAMQRLLGE RLTPREISEV VREADVNGDG TVDFEEFVKM MSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CABP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 360 nTPM

Expression across tissuesHPA

Tissue

retina: 360 nTPM
skin: 0.3 nTPM
bone marrow: 0.2 nTPM
salivary gland: 0.1 nTPM
spleen: 0.1 nTPM
tongue: 0.1 nTPM

Single-cell type

rod photoreceptor cells: 655 nCPM
retinal bipolar cells: 326 nCPM
platelets: 46 nCPM
retinal ganglion cells: 16 nCPM
retinal horizontal cells: 14 nCPM
retinal amacrine cells: 8.4 nCPM

Immune cell

total PBMC: 5 nTPM
basophil: 1.5 nTPM
neutrophil: 0.4 nTPM
T-reg: 0.3 nTPM
classical monocyte: 0.1 nTPM
intermediate monocyte: 0.1 nTPM

Brain region

cerebellum: 2.7 nTPM
cerebral cortex: 2 nTPM
white matter: 1.8 nTPM
choroid plexus: 1.3 nTPM
medulla oblongata: 1.3 nTPM
basal ganglia: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.42
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CABP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CABP5 as an antibody target. Whether an autoantibody or antibody against CABP5 could matter depends on whether native CABP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CABP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CABP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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