Ras of Complex, Roc, domain of DAPkinase

Definition

Roc, or Ras of Complex, proteins are mitochondrial Rho proteins (Miro-1, [swissprot:Q8IXI2], and Miro-2, [swissprot:Q8IXI1]) and atypical Rho GTPases. Full-length proteins have a unique domain organisation, with tandem GTP-binding domains and two EF hand domains ([pfam:PF00036]) that may bind calcium. They are also larger than classical small GTPases. It has been proposed that they are involved in mitochondrial homeostasis and apoptosis [[cite:PMID:14654223],[cite:PMID:12482879],[cite:PMID:15479738],[cite:PMID:18650931]].

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• IFT22
• LRRK1
• LRRK2
• RABL3
• RABL6