PNMA2

Protein identityUniProt · HPA

UniProt accession

Q9UL42

Gene

PNMA2

Ensembl

ENSG00000240694

Chromosome

8

Canonical length

364 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in positive regulation of apoptotic process. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>Q9UL42|PNMA2
     1  MALALLEDWC RIMSVDEQKS LMVTGIPADF EEAEIQEVLQ ETLKSLGRYR LLGKIFRKQE
    61  NANAVLLELL EDTDVSAIPS EVQGKGGVWK VIFKTPNQDT EFLERLNLFL EKEGQTVSGM
   121  FRALGQEGVS PATVPCISPE LLAHLLGQAM AHAPQPLLPM RYRKLRVFSG SAVPAPEEES
   181  FEVWLEQATE IVKEWPVTEA EKKRWLAESL RGPALDLMHI VQADNPSISV EECLEAFKQV
   241  FGSLESRRTA QVRYLKTYQE EGEKVSAYVL RLETLLRRAV EKRAIPRRIA DQVRLEQVMA
   301  GATLNQMLWC RLRELKDQGP PPSFLELMKV IREEEEEEAS FENESIEEPE ERDGYGRWNH
   361  EGDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PNMA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

114 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PNMA2.

Disease | AutoantibodyPubMed

Conditions in which antibodies against PNMA2 are reported. Each links to that disease's full target list.

• Encephalitis 15
• Limbic Encephalitis 15
• Paraneoplastic Syndromes, Nervous System 13
• Lung Neoplasms 7
• Autoimmune Diseases of the Nervous System 6
• Hashimoto Disease 5
• Adenocarcinoma 3
• Brain Diseases 3

Showing 8 of 11 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for PNMA2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.07

gnomAD pLI

0

gnomAD missense Z

0.29

DepMap mean gene effect

0.11

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• positive regulation of apoptotic process

Cellular components

• nucleolus

Protein domainsUniProt · Pfam · InterPro

• Paraneoplastic antigen Ma
• Paraneoplastic antigen Ma-like, C-terminal domain
• Paraneoplastic antigen Ma-like, N-terminal domain
• PNMA
• PNMA N-terminal RRM-like domain

KeywordsUniProt

• Acetylation
• Nucleus
• Tumor antigen

InteractionsUniProt · HPA

Protein binding partners of PNMA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CTNNBIP1
• ENKD1
• FAM161A
• GTPBP4
• HASPIN
• PKN2
• PNMA1
• RECQL4
• ZNF785