Seroatlas · Human Serome Atlas

RABEP1

Rab GTPase-binding effector protein 1

Also known as: neurocrescin, RAB5EP, rabaptin-5, RABE1_HUMAN, RABPT5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15276
Gene
RABEP1
Ensembl
ENSG00000029725
Chromosome
17
Canonical length
862 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Vesicles,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables protein domain specific binding activity and protein homodimerization activity. Involved in vesicle-mediated transport. Located in cytosol; endocytic vesicle; and endosome. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

862 residues, UniProt reviewed canonical sequence.

>Q15276|RABEP1
     1  MAQPGPASQP DVSLQQRVAE LEKINAEFLR AQQQLEQEFN QKRAKFKELY LAKEEDLKRQ
    61  NAVLQAAQDD LGHLRTQLWE AQAEMENIKA IATVSENTKQ EAIDEVKRQW REEVASLQAV
   121  MKETVRDYEH QFHLRLEQER TQWAQYRESA EREIADLRRR LSEGQEEENL ENEMKKAQED
   181  AEKLRSVVMP MEKEIAALKD KLTEAEDKIK ELEASKVKEL NHYLEAEKSC RTDLEMYVAV
   241  LNTQKSVLQE DAEKLRKELH EVCHLLEQER QQHNQLKHTW QKANDQFLES QRLLMRDMQR
   301  MEIVLTSEQL RQVEELKKKD QEDDEQQRLN KRKDHKKADV EEEIKIPVVC ALTQEESSAQ
   361  LSNEEEHLDS TRGSVHSLDA GLLLPSGDPF SKSDNDMFKD GLRRAQSTDS LGTSGSLQSK
   421  ALGYNYKAKS AGNLDESDFG PLVGADSVSE NFDTASLGSL QMPSGFMLTK DQERAIKAMT
   481  PEQEETASLL SSVTQGMESA YVSPSGYRLV SETEWNLLQK EVHNAGNKLG RRCDMCSNYE
   541  KQLQGIQIQE AETRDQVKKL QLMLRQANDQ LEKTMKDKQE LEDFIKQSSE DSSHQISALV
   601  LRAQASEILL EELQQGLSQA KRDVQEQMAV LMQSREQVSE ELVRLQKDND SLQGKHSLHV
   661  SLQQAEDFIL PDTTEALREL VLKYREDIIN VRTAADHVEE KLKAEILFLK EQIQAEQCLK
   721  ENLEETLQLE IENCKEEIAS ISSLKAELER IKVEKGQLES TLREKSQQLE SLQEIKISLE
   781  EQLKKETAAK ATVEQLMFEE KNKAQRLQTE LDVSEQVQRD FVKLSQTLQV QLERIRQADS
   841  LERIRAILND TKLTDINQLP ET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RABEP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
65 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 65 nTPM
  • retina: 54 nTPM
  • tongue: 49 nTPM
  • spinal cord: 46 nTPM
  • parathyroid gland: 45 nTPM
  • midbrain: 43 nTPM

Single-cell type

  • hofbauer cells: 343 nCPM
  • myonuclei: 330 nCPM
  • b-cells: 286 nCPM
  • breast hormone-responsive cells: 266 nCPM
  • prostatic glandular cells: 244 nCPM
  • microglia: 234 nCPM

Immune cell

  • naive B-cell: 98 nTPM
  • memory B-cell: 82 nTPM
  • non-classical monocyte: 52 nTPM
  • plasmacytoid DC: 35 nTPM
  • neutrophil: 31 nTPM
  • gdT-cell: 26 nTPM

Brain region

  • white matter: 107 nTPM
  • hypothalamus: 102 nTPM
  • basal ganglia: 100 nTPM
  • midbrain: 99 nTPM
  • spinal cord: 98 nTPM
  • pons: 96 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
1
gnomAD missense Z
1.86
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RABEP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RABEP1 as an antibody target. Whether an autoantibody or antibody against RABEP1 could matter depends on whether native RABEP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RABEP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RABEP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RABEP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...