Seroatlas · Human Serome Atlas

PTGDR

Prostaglandin D2 receptor

Also known as: DP, DP1, PD2R_HUMAN, PTGDR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13258
Gene
PTGDR
Ensembl
ENSG00000168229
Chromosome
14
Canonical length
359 aa
Protein class
Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>Q13258|PTGDR
     1  MKSPFYRCQN TTSVEKGNSA VMGGVLFSTG LLGNLLALGL LARSGLGWCS RRPLRPLPSV
    61  FYMLVCGLTV TDLLGKCLLS PVVLAAYAQN RSLRVLAPAL DNSLCQAFAF FMSFFGLSST
   121  LQLLAMALEC WLSLGHPFFY RRHITLRLGA LVAPVVSAFS LAFCALPFMG FGKFVQYCPG
   181  TWCFIQMVHE EGSLSVLGYS VLYSSLMALL VLATVLCNLG AMRNLYAMHR RLQRHPRSCT
   241  RDCAEPRADG REASPQPLEE LDHLLLLALM TVLFTMCSLP VIYRAYYGAF KDVKEKNRTS
   301  EEAEDLRALR FLSVISIVDP WIFIIFRSPV FRIFFHKIFI RPLRYRSRCS NSTNMESSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTGDR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
7.4 nTPM

Expression across tissuesHPA

Tissue

  • rectum: 7.4 nTPM
  • spleen: 5.9 nTPM
  • colon: 5.2 nTPM
  • lymph node: 3 nTPM
  • appendix: 2 nTPM
  • adipose tissue: 1.9 nTPM

Single-cell type

  • nk-cells: 167 nCPM
  • platelets: 85 nCPM
  • t-cells: 62 nCPM
  • innate lymphoid cells: 58 nCPM
  • enteric stem cells: 48 nCPM
  • enteric transient amplifying cells: 35 nCPM

Immune cell

  • NK-cell: 91 nTPM
  • gdT-cell: 68 nTPM
  • memory CD8 T-cell: 41 nTPM
  • MAIT T-cell: 34 nTPM
  • naive CD8 T-cell: 23 nTPM
  • total PBMC: 13 nTPM

Brain region

  • choroid plexus: 6.3 nTPM
  • medulla oblongata: 6.1 nTPM
  • basal ganglia: 4.3 nTPM
  • spinal cord: 3.7 nTPM
  • cerebellum: 2.2 nTPM
  • cerebral cortex: 1.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PTGDR.

Disease | AllUniProt

Conditions PTGDR is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.5
gnomAD pLI
0
gnomAD missense Z
-0.94
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PTGDR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTGDR as an antibody target. Whether an autoantibody or antibody against PTGDR could matter depends on whether native PTGDR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTGDR is annotated at the cell surface, where native PTGDR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PTGDR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTGDR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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