Seroatlas · Human Serome Atlas

M6PR

Cation-dependent mannose-6-phosphate receptor

Also known as: CD-M6PR, CD-MPR, MPRD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P20645
Gene
M6PR
Ensembl
ENSG00000003056
Chromosome
12
Canonical length
277 aa
Protein class
FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

277 residues, UniProt reviewed canonical sequence.

>P20645|M6PR
     1  MFPFYSCWRT GLLLLLLAVA VRESWQTEEK TCDLVGEKGK ESEKELALVK RLKPLFNKSF
    61  ESTVGQGSDT YIYIFRVCRE AGNHTSGAGL VQINKSNGKE TVVGRLNETH IFNGSNWIML
   121  IYKGGDEYDN HCGKEQRRAV VMISCNRHTL ADNFNPVSEE RGKVQDCFYL FEMDSSLACS
   181  PEISHLSVGS ILLVTFASLV AVYVVGGFLY QRLVVGAKGM EQFPHLAFWQ DLGNLVADGC
   241  DFVCRSKPRN VPAAYRGVGD DQLGEESEER DDHLLPM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against M6PR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
130 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 130 nTPM
  • spleen: 125 nTPM
  • tonsil: 118 nTPM
  • appendix: 108 nTPM
  • thymus: 98 nTPM
  • bone marrow: 98 nTPM

Single-cell type

  • hofbauer cells: 119 nCPM
  • platelets: 92 nCPM
  • monocytes: 89 nCPM
  • macrophages: 87 nCPM
  • early primary spermatocytes: 82 nCPM
  • cdc: 82 nCPM

Immune cell

  • basophil: 709 nTPM
  • non-classical monocyte: 571 nTPM
  • total PBMC: 499 nTPM
  • intermediate monocyte: 479 nTPM
  • myeloid DC: 335 nTPM
  • eosinophil: 321 nTPM

Brain region

  • white matter: 92 nTPM
  • thalamus: 83 nTPM
  • hypothalamus: 72 nTPM
  • pons: 71 nTPM
  • medulla oblongata: 69 nTPM
  • spinal cord: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0.01
gnomAD missense Z
0.98
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of M6PR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads M6PR as an antibody target. Whether an autoantibody or antibody against M6PR could matter depends on whether native M6PR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

M6PR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label M6PR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/M6PR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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