Seroatlas · Human Serome Atlas

ADRA2B

Alpha-2B adrenergic receptor

Also known as: ADA2B_HUMAN, ADRA2L1, ADRA2RL1, ADRARL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P18089
Gene
ADRA2B
Ensembl
ENSG00000274286
Chromosome
2
Canonical length
450 aa
Protein class
Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

450 residues, UniProt reviewed canonical sequence.

>P18089|ADRA2B
     1  MDHQDPYSVQ ATAAIAAAIT FLILFTIFGN ALVILAVLTS RSLRAPQNLF LVSLAAADIL
    61  VATLIIPFSL ANELLGYWYF RRTWCEVYLA LDVLFCTSSI VHLCAISLDR YWAVSRALEY
   121  NSKRTPRRIK CIILTVWLIA AVISLPPLIY KGDQGPQPRG RPQCKLNQEA WYILASSIGS
   181  FFAPCLIMIL VYLRIYLIAK RSNRRGPRAK GGPGQGESKQ PRPDHGGALA SAKLPALASV
   241  ASAREVNGHS KSTGEKEEGE TPEDTGTRAL PPSWAALPNS GQGQKEGVCG ASPEDEAEEE
   301  EEEEEEEEEC EPQAVPVSPA SACSPPLQQP QGSRVLATLR GQVLLGRGVG AIGGQWWRRR
   361  AQLTREKRFT FVLAVVIGVF VLCWFPFFFS YSLGAICPKH CKVPHGLFQF FFWIGYCNSS
   421  LNPVIYTIFN QDFRRAFRRI LCRPWTQTAW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADRA2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
9.4 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 9.4 nTPM
  • spleen: 7.9 nTPM
  • kidney: 7.8 nTPM
  • blood vessel: 7.2 nTPM
  • liver: 6.3 nTPM
  • adipose tissue: 6 nTPM

Single-cell type

  • pericytes: 17 nCPM
  • endometrial glandular cells: 9.3 nCPM
  • epididymal principal cells: 9 nCPM
  • vascular smooth muscle cells: 9 nCPM
  • endometrial luminal cells: 8.8 nCPM
  • retinal pigment epithelial cells: 8.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 9.5 nTPM
  • cerebral cortex: 4.7 nTPM
  • thalamus: 4.6 nTPM
  • white matter: 4 nTPM
  • medulla oblongata: 3 nTPM
  • basal ganglia: 2.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ADRA2B.

Disease | AllUniProt

Conditions ADRA2B is implicated in, by any mechanism.

  • Epilepsy, familial adult myoclonic, 2 (FAME2) MIM:607876

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
0.37
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADRA2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADRA2B as an antibody target. Whether an autoantibody or antibody against ADRA2B could matter depends on whether native ADRA2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADRA2B is annotated at the cell surface, where native ADRA2B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADRA2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADRA2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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