Seroatlas · Human Serome Atlas

CCDC91

Coiled-coil domain-containing protein 91

Also known as: CCD91_HUMAN, DKFZp779L1558, FLJ11088, p56

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z6B0
Gene
CCDC91
Ensembl
ENSG00000123106
Chromosome
12
Canonical length
441 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Acrosome,Equatorial segment,Flagellar centriole
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to enable identical protein binding activity. Involved in Golgi to lysosome transport. Located in nucleoplasm and trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

441 residues, UniProt reviewed canonical sequence.

>Q7Z6B0|CCDC91
     1  MDDDDFGGFE AAETFDGGSG ETQTTSPAIP WAAFPAVSGV HLSPSSPEIV LDRDHSSSIG
    61  CLSSDAIISS PENTHAANSI VSQTIPKAQI QQSTHTHLDI SLFPLGLTDE KSNGTIALVD
   121  DSEDPGANVS NIQLQQKISS LEIKLKVSEE EKQRIKQDVE SLMEKHNVLE KGFLKEKEQE
   181  AISFQDRYKE LQEKHKQELE DMRKAGHEAL SIIVDEYKAL LQSSVKQQVE AIEKQYISAI
   241  EKQAHKCEEL LNAQHQRLLE MLDTEKELLK EKIKEALIQQ SQEQKEILEK CLEEERQRNK
   301  EALVSAAKLE KEAVKDAVLK VVEEERKNLE KAHAEERELW KTEHAKDQEK VSQEIQKAIQ
   361  EQRKISQETV KAAIIEEQKR SEKAVEEAVK RTRDELIEYI KEQKRLDQVI RQRSLSSLEL
   421  FLSCAQKQLS ALIATEPVDI E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC91 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 41 nTPM
  • testis: 31 nTPM
  • heart muscle: 31 nTPM
  • parathyroid gland: 30 nTPM
  • pancreas: 27 nTPM
  • retina: 25 nTPM

Single-cell type

  • late spermatids: 14,270 nCPM
  • early spermatids: 2,902 nCPM
  • podocytes: 2,596 nCPM
  • late primary spermatocytes: 852 nCPM
  • thyrotrophs: 511 nCPM
  • choroid plexus epithelial cells: 493 nCPM

Immune cell

  • basophil: 37 nTPM
  • naive B-cell: 20 nTPM
  • memory B-cell: 19 nTPM
  • T-reg: 19 nTPM
  • NK-cell: 15 nTPM
  • naive CD4 T-cell: 15 nTPM

Brain region

  • cerebral cortex: 107 nTPM
  • cerebellum: 95 nTPM
  • pons: 93 nTPM
  • white matter: 89 nTPM
  • thalamus: 83 nTPM
  • amygdala: 81 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0
gnomAD missense Z
0.43
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Coiled-coil domain-containing protein 91

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC91 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC91 as an antibody target. Whether an autoantibody or antibody against CCDC91 could matter depends on whether native CCDC91 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC91 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC91 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC91. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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