Seroatlas · Human Serome Atlas

CNST

Consortin

Also known as: C1orf71, CNST_HUMAN, FLJ32001, PPP1R64

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PJW8
Gene: CNST
Ensembl: ENSG00000162852
Chromosome: 1
Canonical length: 725 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]).[supplied by OMIM, Jun 2010]

Canonical amino-acid sequenceUniProt

725 residues, UniProt reviewed canonical sequence.

>Q6PJW8|CNST
     1  MDDSDTPTYY LQIEPQDGCH PGDSVERSVT CLPSASDENE NQLDGDGHEH LTSSDSAMGK
    61  PQVSEQDSLN NNESCTLSCE VAAGENLQNT LCEASRDEQA FLGKDKKIPG KRSPRSKKGT
   121  AKKIPPGLFS GDIAPLMQEK VLSAVTYAVD DEEAAEVNAN EQPEAPKLVL QSLFSLIRGE
   181  VEQLDSRALP LCLHQIAESY FQEEDYEKAM KFIQLERLYH EQLLANLSAI QEQWETKWKT
   241  VQPHTVTALR NSEKGFNGED FERLTKICAT HQDPLLSKHK IAAVEKSQER KCSTQLLVSE
   301  DPKEGGATTK ESESKTCLGT ESSKESQHTV EPLGSSPCCH QMDVQTDSPS LSVTAGKDHM
   361  EELLCSAEAT LALHTQSSET AGSPSGPDSS EDACEDDSRL QLAQTEACQD VARIEGIAED
   421  PKVFLSSKSK TEPLISPGCD RIPPALISEG KYSQAQRKEL RLPLRDASEA LPTDQLENNE
   481  LNELQQPDLT DSDGKSPQAQ ADSDGSENVL CGNNQISDLG ILLPEVCMAP EEKGDKDDQL
   541  NKETEDYLNS LLEGCLKDTE DSLSYEDNQD DDSDLLQDLS PEEASYSLQE NLPSDESCLS
   601  LDDLAKRIEI AEVVPTEGLV SILKKRNDTV GDHPAQMQHK PSKRRVRFQE IDDSLDQDEV
   661  GGGSCILLVL LCIATVFLSV GGTALYCTFG DMESPVCTDF ADNMDFYYTK LLQGVAELKH
   721  WIYLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNST can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

tongue: 36 nTPM
skeletal muscle: 30 nTPM
bone marrow: 22 nTPM
liver: 22 nTPM
adrenal gland: 18 nTPM
cerebellum: 16 nTPM

Single-cell type

platelets: 1,231 nCPM
endometrial glandular cells: 419 nCPM
thymic myoid cells: 366 nCPM
hematopoietic stem cells: 359 nCPM
megakaryocyte progenitors: 296 nCPM
mast cells: 293 nCPM

Immune cell

basophil: 47 nTPM
memory B-cell: 36 nTPM
naive B-cell: 36 nTPM
T-reg: 33 nTPM
naive CD4 T-cell: 31 nTPM
memory CD4 T-cell: 25 nTPM

Brain region

choroid plexus: 41 nTPM
cerebral cortex: 38 nTPM
cerebellum: 34 nTPM
hypothalamus: 28 nTPM
basal ganglia: 24 nTPM
white matter: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0
gnomAD missense Z: 0
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of Golgi to plasma membrane protein transport

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Consortin, C-terminal domain
Consortin
Consortin, N-terminal domain
Consortin C-terminus
Consortin, N-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CNST in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNST as an antibody target. Whether an autoantibody or antibody against CNST could matter depends on whether native CNST is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNST is annotated at the cell surface, where native CNST is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CNST as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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