Seroatlas · Human Serome Atlas

TMOD3

Tropomodulin-3

Also known as: TMOD3_HUMAN, UTMOD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYL9
Gene: TMOD3
Ensembl: ENSG00000138594
Chromosome: 15
Canonical length: 352 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Actin filaments,Cytosol

OverviewNCBI Gene

Enables cadherin binding activity involved in cell-cell adhesion. Predicted to be involved in actin filament organization; muscle contraction; and myofibril assembly. Predicted to act upstream of or within actin cytoskeleton organization; erythrocyte development; and positive regulation of mitotic cell cycle phase transition. Located in adherens junction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

352 residues, UniProt reviewed canonical sequence.

>Q9NYL9|TMOD3
     1  MALPFRKDLE KYKDLDEDEL LGNLSETELK QLETVLDDLD PENALLPAGF RQKNQTSKST
    61  TGPFDREHLL SYLEKEALEH KDREDYVPYT GEKKGKIFIP KQKPVQTFTE EKVSLDPELE
   121  EALTSASDTE LCDLAAILGM HNLITNTKFC NIMGSSNGVD QEHFSNVVKG EKILPVFDEP
   181  PNPTNVEESL KRTKENDAHL VEVNLNNIKN IPIPTLKDFA KALETNTHVK CFSLAATRSN
   241  DPVATAFAEM LKVNKTLKSL NVESNFITGV GILALIDALR DNETLAELKI DNQRQQLGTA
   301  VELEMAKMLE ENTNILKFGY QFTQQGPRTR AANAITKNND LVRKRRVEGD HQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMOD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

esophagus: 41 nTPM
placenta: 21 nTPM
lung: 21 nTPM
tonsil: 18 nTPM
vagina: 18 nTPM
stomach: 16 nTPM

Single-cell type

esophageal apical cells: 1,943 nCPM
alveolar cells type 1: 724 nCPM
mast cells: 518 nCPM
neutrophils: 518 nCPM
ocular epithelial cells: 506 nCPM
neutrophil progenitors: 462 nCPM

Immune cell

basophil: 48 nTPM
neutrophil: 46 nTPM
eosinophil: 42 nTPM
non-classical monocyte: 40 nTPM
intermediate monocyte: 35 nTPM
plasmacytoid DC: 29 nTPM

Brain region

choroid plexus: 18 nTPM
thalamus: 16 nTPM
midbrain: 15 nTPM
medulla oblongata: 14 nTPM
spinal cord: 14 nTPM
amygdala: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0.07
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMOD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMOD3 as an antibody target. Whether an autoantibody or antibody against TMOD3 could matter depends on whether native TMOD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMOD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMOD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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