Seroatlas · Human Serome Atlas

TMOD1

Tropomodulin-1

Also known as: D9S57E, ETMOD, TMOD, TMOD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P28289
Gene
TMOD1
Ensembl
ENSG00000136842
Chromosome
9
Canonical length
359 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

359 residues, UniProt reviewed canonical sequence.

>P28289|TMOD1
     1  MSYRRELEKY RDLDEDEILG ALTEEELRTL ENELDELDPD NALLPAGLRQ KDQTTKAPTG
    61  PFKREELLDH LEKQAKEFKD REDLVPYTGE KRGKVWVPKQ KPLDPVLESV TLEPELEEAL
   121  ANASDAELCD IAAILGMHTL MSNQQYYQAL SSSSIMNKEG LNSVIKPTQY KPVPDEEPNS
   181  TDVEETLERI KNNDPKLEEV NLNNIRNIPI PTLKAYAEAL KENSYVKKFS IVGTRSNDPV
   241  AYALAEMLKE NKVLKTLNVE SNFISGAGIL RLVEALPYNT SLVEMKIDNQ SQPLGNKVEM
   301  EIVSMLEKNA TLLKFGYHFT QQGPRLRASN AMMNNNDLVR KRRLADLTGP IIPKCRSGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMOD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
239 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 239 nTPM
  • skeletal muscle: 234 nTPM
  • heart muscle: 135 nTPM
  • blood vessel: 73 nTPM
  • adrenal gland: 62 nTPM
  • ovary: 49 nTPM

Single-cell type

  • adrenal medulla cells: 564 nCPM
  • pancreatic islet cells: 406 nCPM
  • pituitary stem cells: 327 nCPM
  • retinal horizontal cells: 252 nCPM
  • mast cells: 194 nCPM
  • cardiomyocytes: 175 nCPM

Immune cell

  • T-reg: 2.2 nTPM
  • naive B-cell: 2 nTPM
  • gdT-cell: 1.2 nTPM
  • memory B-cell: 1.2 nTPM
  • MAIT T-cell: 1.1 nTPM
  • total PBMC: 1.1 nTPM

Brain region

  • hypothalamus: 41 nTPM
  • cerebellum: 38 nTPM
  • white matter: 33 nTPM
  • cerebral cortex: 31 nTPM
  • medulla oblongata: 29 nTPM
  • basal ganglia: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0.48
gnomAD missense Z
1.23
DepMap mean gene effect
-0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMOD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMOD1 as an antibody target. Whether an autoantibody or antibody against TMOD1 could matter depends on whether native TMOD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMOD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMOD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMOD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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