Villin/Gelsolin

Definition

Gelsolin is an actin-modulating protein that severs F-actin, caps the barbed ends of actin filaments preventing monomer exchange, and promotes the nucleation step of actin polymerisation [[cite:PMID:14527663], [cite:PMID:3023087]]. It can be regulated by Ca2+ and phosphoinositides PMID:3027569. The interaction between gelsolin and tropomyosin modulates actin dynamics PMID:23844991. Gelsolin also plays a role in ciliogenesis PMID:20393563. The structure of gelsolin has been solved PMID:9288746.

8 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (8 proteins: gene, accession, name)

• AVIL
• CAPG
• FLII
• GSN
• SCIN
• SVIL
• VIL1
• VILL