Seroatlas · Human Serome Atlas

LMOD2

Leiomodin-2

Also known as: LMOD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P5Q4
Gene: LMOD2
Ensembl: ENSG00000170807
Chromosome: 7
Canonical length: 547 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Plasma membrane,Actin filaments,Cytosol

OverviewNCBI Gene

Enables actin monomer binding activity and tropomyosin binding activity. Involved in actin nucleation; positive regulation of actin filament polymerization; and sarcomere organization. Located in M band and actin filament. Implicated in dilated cardiomyopathy 2G. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

547 residues, UniProt reviewed canonical sequence.

>Q6P5Q4|LMOD2
     1  MSTFGYRRGL SKYESIDEDE LLASLSAEEL KELERELEDI EPDRNLPVGL RQKSLTEKTP
    61  TGTFSREALM AYWEKESQKL LEKERLGECG KVAEDKEESE EELIFTESNS EVSEEVYTEE
   121  EEEESQEEEE EEDSDEEERT IETAKGINGT VNYDSVNSDN SKPKIFKSQI ENINLTNGSN
   181  GRNTESPAAI HPCGNPTVIE DALDKIKSND PDTTEVNLNN IENITTQTLT RFAEALKDNT
   241  VVKTFSLANT HADDSAAMAI AEMLKVNEHI TNVNVESNFI TGKGILAIMR ALQHNTVLTE
   301  LRFHNQRHIM GSQVEMEIVK LLKENTTLLR LGYHFELPGP RMSMTSILTR NMDKQRQKRL
   361  QEQKQQEGYD GGPNLRTKVW QRGTPSSSPY VSPRHSPWSS PKLPKKVQTV RSRPLSPVAT
   421  PPPPPPPPPP PPPSSQRLPP PPPPPPPPLP EKKLITRNIA EVIKQQESAQ RALQNGQKKK
   481  KGKKVKKQPN SILKEIKNSL RSVQEKKMED SSRPSTPQRS AHENLMEAIR GSSIKQLKRV
   541  EVPEALR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LMOD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 874 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 874 nTPM
tongue: 741 nTPM
heart muscle: 729 nTPM
esophagus: 20 nTPM
salivary gland: 10 nTPM
prostate: 9.6 nTPM

Single-cell type

thymic myoid cells: 559 nCPM
myonuclei: 448 nCPM
cardiomyocytes: 142 nCPM
parietal cells: 25 nCPM
epicardial cells: 14 nCPM
endometrial secretory cells: 7.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.3 nTPM
hippocampal formation: 0.9 nTPM
choroid plexus: 0.8 nTPM
midbrain: 0.6 nTPM
basal ganglia: 0.5 nTPM
cerebellum: 0.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LMOD2.

Disease | AllUniProt

Conditions LMOD2 is implicated in, by any mechanism.

Cardiomyopathy, dilated, 2G (CMD2G) MIM:619897

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 101 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Cardiomyopathy, dilated, 2G
Familial isolated dilated cardiomyopathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LMOD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FLII

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LMOD2 as an antibody target. Whether an autoantibody or antibody against LMOD2 could matter depends on whether native LMOD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LMOD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LMOD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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