Seroatlas · Human Serome Atlas

FGF7

Fibroblast growth factor 7

Also known as: FGF7_HUMAN, KGF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P21781
Gene
FGF7
Ensembl
ENSG00000140285
Chromosome
15
Canonical length
194 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins
Subcellular location
Nucleoplasm,Nucleoli
Secretome location
Secreted in other tissues

OverviewNCBI Gene

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

194 residues, UniProt reviewed canonical sequence.

>P21781|FGF7
     1  MHKWILTWIL PTLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE RHTRSYDYME
    61  GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA
   121  MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK
   181  KEQKTAHFLP MAIT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGF7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
59 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 59 nTPM
  • adipose tissue: 47 nTPM
  • fallopian tube: 47 nTPM
  • cervix: 44 nTPM
  • gallbladder: 43 nTPM
  • lung: 40 nTPM

Single-cell type

  • fibroblasts: 357 nCPM
  • fibro-adipogenic progenitors: 246 nCPM
  • smooth muscle cells: 167 nCPM
  • pericytes: 164 nCPM
  • decidual stromal cells: 161 nCPM
  • leydig cells: 108 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • NK-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • pons: 11 nTPM
  • hypothalamus: 10 nTPM
  • midbrain: 10 nTPM
  • medulla oblongata: 9.9 nTPM
  • thalamus: 9.5 nTPM
  • white matter: 9.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.77
gnomAD missense Z
1.49
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FGF7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGF7 as an antibody target. Whether an autoantibody or antibody against FGF7 could matter depends on whether native FGF7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGF7 is annotated as secreted, so native FGF7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FGF7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FGF7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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