Seroatlas · Human Serome Atlas

FGF10

Fibroblast growth factor 10

Also known as: FGF10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15520
Gene
FGF10
Ensembl
ENSG00000070193
Chromosome
5
Canonical length
208 aa
Protein class
Disease related genes, Human disease related genes, Predicted secreted proteins, RAS pathway related proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>O15520|FGF10
     1  MWKWILTHCA SAFPHLPGCC CCCFLLLFLV SSVPVTCQAL GQDMVSPEAT NSSSSSFSSP
    61  SSAGRHVRSY NHLQGDVRWR KLFSFTKYFL KIEKNGKVSG TKKENCPYSI LEITSVEIGV
   121  VAVKAINSNY YLAMNKKGKL YGSKEFNNDC KLKERIEENG YNTYASFNWQ HNGRQMYVAL
   181  NGKGAPRRGQ KTRRKNTSAH FLPMVVHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGF10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • breast: 11 nTPM
  • ovary: 9.7 nTPM
  • adipose tissue: 9.4 nTPM
  • vagina: 9.1 nTPM
  • cervix: 8.4 nTPM
  • fallopian tube: 5.8 nTPM

Single-cell type

  • fibro-adipogenic progenitors: 155 nCPM
  • pituicytes/fscs: 117 nCPM
  • endometrial stromal cells: 110 nCPM
  • fibroblasts: 106 nCPM
  • leydig cells: 71 nCPM
  • adipocytes: 59 nCPM

Immune cell

  • basophil: 0.5 nTPM
  • eosinophil: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • midbrain: 5.2 nTPM
  • hypothalamus: 4.7 nTPM
  • spinal cord: 4.5 nTPM
  • medulla oblongata: 3.9 nTPM
  • pons: 3.6 nTPM
  • choroid plexus: 3.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FGF10.

Disease | AllUniProt

Conditions FGF10 is implicated in, by any mechanism.

  • Aplasia of lacrimal and salivary glands (ALSG) MIM:180920
  • Lacrimo-auriculo-dento-digital syndrome 3 (LADD3) MIM:620193

Disease | GeneticClinVar

26 pathogenic / likely-pathogenic of 124 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.94
gnomAD missense Z
0.85
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FGF10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGF10 as an antibody target. Whether an autoantibody or antibody against FGF10 could matter depends on whether native FGF10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGF10 is annotated as secreted, so native FGF10 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FGF10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FGF10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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