Seroatlas · Human Serome Atlas

FGF16

Fibroblast growth factor 16

Also known as: FGF16_HUMAN, MF4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43320
Gene
FGF16
Ensembl
ENSG00000196468
Chromosome
X
Canonical length
207 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

207 residues, UniProt reviewed canonical sequence.

>O43320|FGF16
     1  MAEVGGVFAS LDWDLHGFSS SLGNVPLADS PGFLNERLGQ IEGKLQRGSP TDFAHLKGIL
    61  RRRQLYCRTG FHLEIFPNGT VHGTRHDHSR FGILEFISLA VGLISIRGVD SGLYLGMNER
   121  GELYGSKKLT RECVFREQFE ENWYNTYAST LYKHSDSERQ YYVALNKDGS PREGYRTKRH
   181  QKFTHFLPRP VDPSKLPSMS RDLFHYR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGF16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
4.2 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 4.2 nTPM
  • adipose tissue: 0.6 nTPM
  • breast: 0.4 nTPM
  • tongue: 0.4 nTPM
  • blood vessel: 0.2 nTPM
  • skeletal muscle: 0.2 nTPM

Single-cell type

  • fibro-adipogenic progenitors: 3.5 nCPM
  • salivary ionocytes: 1.8 nCPM
  • choroid plexus epithelial cells: 1.6 nCPM
  • hematopoietic stem cells: 1.5 nCPM
  • fibroblasts: 1.1 nCPM
  • cardiomyocytes: 0.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 3.6 nTPM
  • hypothalamus: 1 nTPM
  • basal ganglia: 0.6 nTPM
  • medulla oblongata: 0.6 nTPM
  • pons: 0.6 nTPM
  • cerebral cortex: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FGF16.

Disease | AllUniProt

Conditions FGF16 is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 17 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Syndactyly type 8
  • FGF16-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0.75
gnomAD missense Z
0.88

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FGF16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGF16 as an antibody target. Whether an autoantibody or antibody against FGF16 could matter depends on whether native FGF16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGF16 is annotated as secreted, so native FGF16 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FGF16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FGF16. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...