Seroatlas · Human Serome Atlas

FGF19

Fibroblast growth factor 19

Also known as: FGF19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95750
Gene
FGF19
Ensembl
ENSG00000162344
Chromosome
11
Canonical length
216 aa
Protein class
Cancer-related genes, Predicted secreted proteins, RAS pathway related proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

216 residues, UniProt reviewed canonical sequence.

>O95750|FGF19
     1  MRSGCVVVHV WILAGLWLAV AGRPLAFSDA GPHVHYGWGD PIRLRHLYTS GPHGLSSCFL
    61  RIRADGVVDC ARGQSAHSLL EIKAVALRTV AIKGVHSVRY LCMGADGKMQ GLLQYSEEDC
   121  AFEEEIRPDG YNVYRSEKHR LPVSLSSAKQ RQLYKNRGFL PLSHFLPMLP MVPEEPEDLR
   181  GHLESDMFSS PLETDSMDPF GLVTGLEAVR SPSFEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGF19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
223 nTPM

Expression across tissuesHPA

Tissue

  • gallbladder: 223 nTPM
  • small intestine: 11 nTPM
  • parathyroid gland: 1.2 nTPM
  • liver: 0.7 nTPM
  • epididymis: 0.4 nTPM
  • cerebellum: 0.2 nTPM

Single-cell type

  • epididymal basal cells: 22 nCPM
  • cholangiocytes: 18 nCPM
  • enterocytes: 14 nCPM
  • pancreatic duct cells: 9.3 nCPM
  • epididymal efferent duct absorptive cells: 8.6 nCPM
  • endometrial secretory cells: 2.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 0.5 nTPM
  • thalamus: 0.3 nTPM
  • cerebellum: 0.2 nTPM
  • midbrain: 0.2 nTPM
  • hypothalamus: 0.1 nTPM
  • pons: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0.57
gnomAD missense Z
0.93
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FGF19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGF19 as an antibody target. Whether an autoantibody or antibody against FGF19 could matter depends on whether native FGF19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGF19 is annotated as secreted, so native FGF19 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FGF19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FGF19. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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