FGF5

Protein identityUniProt · HPA

UniProt accession

P12034

Gene

FGF5

Ensembl

ENSG00000138675

Chromosome

4

Canonical length

268 aa

Protein class

Disease related genes, Human disease related genes, Predicted secreted proteins, RAS pathway related proteins

Secretome location

Secreted in brain

OverviewNCBI Gene

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

268 residues, UniProt reviewed canonical sequence.

>P12034|FGF5
     1  MSLSFLLLLF FSHLILSAWA HGEKRLAPKG QPGPAATDRN PRGSSSRQSS SSAMSSSSAS
    61  SSPAASLGSQ GSGLEQSSFQ WSPSGRRTGS LYCRVGIGFH LQIYPDGKVN GSHEANMLSV
   121  LEIFAVSQGI VGIRGVFSNK FLAMSKKGKL HASAKFTDDC KFRERFQENS YNTYASAIHR
   181  TEKTGREWYV ALNKRGKAKR GCSPRVKPQH ISTHFLPRFK QSEQPELSFT VTVPEKKKPP
   241  SPIKPKIPLS APRKNTNSVK YRLKFRFG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGF5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.49

Highest tissue expression

2.8 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FGF5.

Disease | AllUniProt

Conditions FGF5 is implicated in, by any mechanism.

• Trichomegaly (TCMGLY) MIM:190330

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 64 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Trichomegaly

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.88

gnomAD pLI

0

gnomAD missense Z

-0.6

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell-cell signaling
• fibroblast growth factor receptor signaling pathway
• glial cell differentiation
• nervous system development
• neurogenesis
• positive regulation of cell division
• positive regulation of cell population proliferation
• positive regulation of MAPK cascade
• regulation of cell migration
• signal transduction involved in regulation of gene expression

Molecular functions

• fibroblast growth factor receptor binding
• growth factor activity

Cellular components

• cytoplasm
• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Fibroblast growth factor family
• Cytokine IL1/FGF
• Fibroblast growth factor

KeywordsUniProt

• Glycoprotein
• Growth factor
• Mitogen
• Proto-oncogene
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of FGF5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FGFR1
• FGFR2