FGF20

Protein identityUniProt · HPA

UniProt accession

Q9NP95

Gene

FGF20

Ensembl

ENSG00000078579

Chromosome

8

Canonical length

211 aa

Protein class

Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins

Secretome location

Secreted in other tissues

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

211 residues, UniProt reviewed canonical sequence.

>Q9NP95|FGF20
     1  MAPLAEVGGF LGGLEGLGQQ VGSHFLLPPA GERPPLLGER RSAAERSARG GPGAAQLAHL
    61  HGILRRRQLY CRTGFHLQIL PDGSVQGTRQ DHSLFGILEF ISVAVGLVSI RGVDSGLYLG
   121  MNDKGELYGS EKLTSECIFR EQFEENWYNT YSSNIYKHGD TGRRYFVALN KDGTPRDGAR
   181  SKRHQKFTHF LPRPVDPERV PELYKDLLMY T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGF20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

2.7 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FGF20.

Disease | AllUniProt

Conditions FGF20 is implicated in, by any mechanism.

• Renal hypodysplasia/aplasia 2 (RHDA2) MIM:615721

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 135 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Renal hypodysplasia/aplasia 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.54

gnomAD pLI

0.81

gnomAD missense Z

-0.87

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell-cell signaling
• fibroblast growth factor receptor signaling pathway
• inner ear auditory receptor cell differentiation
• negative regulation of neuron apoptotic process
• neurogenesis
• positive regulation of cell population proliferation
• positive regulation of dopaminergic neuron differentiation
• positive regulation of ERK1 and ERK2 cascade
• positive regulation of MAPK cascade
• regulation of cardiac muscle cell proliferation
• regulation of cell migration
• regulation of dopamine secretion
• signal transduction

Molecular functions

• fibroblast growth factor receptor binding
• growth factor activity
• heparan sulfate proteoglycan binding
• receptor-receptor interaction
• signaling receptor binding

Cellular components

• cytoplasm
• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Fibroblast growth factor family
• Cytokine IL1/FGF
• Fibroblast growth factor

KeywordsUniProt

• Growth factor
• Secreted

InteractionsUniProt · HPA

Protein binding partners of FGF20 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FGFR2
• FGFR4