Seroatlas · Human Serome Atlas

FGF6

Fibroblast growth factor 6

Also known as: FGF6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P10767
Gene
FGF6
Ensembl
ENSG00000111241
Chromosome
12
Canonical length
208 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>P10767|FGF6
     1  MALGQKLFIT MSRGAGRLQG TLWALVFLGI LVGMVVPSPA GTRANNTLLD SRGWGTLLSR
    61  SRAGLAGEIA GVNWESGYLV GIKRQRRLYC NVGIGFHLQV LPDGRISGTH EENPYSLLEI
   121  STVERGVVSL FGVRSALFVA MNSKGRLYAT PSFQEECKFR ETLLPNNYNA YESDLYQGTY
   181  IALSKYGRVK RGSKVSPIMT VTHFLPRI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGF6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 13 nTPM
  • tongue: 8.9 nTPM
  • esophagus: 0.5 nTPM
  • salivary gland: 0.1 nTPM
  • testis: 0.1 nTPM
  • adipose tissue: 0 nTPM

Single-cell type

  • myonuclei: 34 nCPM
  • medullary thymic epithelial cells: 2.4 nCPM
  • retinal horizontal cells: 2 nCPM
  • early spermatids: 1.2 nCPM
  • fibro-adipogenic progenitors: 0.8 nCPM
  • late primary spermatocytes: 0.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 1.3 nTPM
  • cerebral cortex: 1.1 nTPM
  • hippocampal formation: 1 nTPM
  • basal ganglia: 0.9 nTPM
  • hypothalamus: 0.4 nTPM
  • medulla oblongata: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.43
gnomAD pLI
0
gnomAD missense Z
0.43
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FGF6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGF6 as an antibody target. Whether an autoantibody or antibody against FGF6 could matter depends on whether native FGF6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGF6 is annotated as secreted, so native FGF6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FGF6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FGF6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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